FAILURE TO REVERSE CHOLERA TOXIN INDUCED INTESTINAL SECRETION BY AGENTS WHICH DECREASE MUCOSAL CAMP

被引：11

作者：

FORSYTH, GW

HAMILTON, DL

SCOOT, A

GOERTZ, KE

KAPITANY, RA

机构：

[1] UNIV SASKATCHEWAN, SASKATOON S7N 0W0, SASKATCHEWAN, CANADA

[2] UNIV SASKATCHEWAN, VET INFECT DIS ORG, SASKATOON S7N 0W0, SASKATCHEWAN, CANADA

来源：

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY | 1979年 / 57卷 / 09期

关键词：

D O I：

10.1139/y79-150

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The feasibility of reducing intestinal secretion by the use of agents which decrease intestinal mucosal c[cyclic]AMP concentration was investigated in the weanling pig and the rabbit. Three different agents for decreasing mucosal cAMP concentration were studied. The cyclic nucleotide phosphodiesterase activator, imidazole, significantly reduced mucosal cAMP concentrations only in the weanling pig. Intraluminal 2''-deoxyadenosine-3''-AMP inhibited adenylate cyclase and caused a decrease in mucosal cAMP concentration in the pig and the rabbit. The introduction of the heat-stable enterotoxin of Escherichia coli into pig jejunal segments gave lowered mucosal cAMP concentrations. While these 3 agents effectively reduced cAMP concentrations in intestinal mucosa, they were ineffective in reducing the net fluid secretory effects of cholera toxin. Secretion caused by cholera toxin apparently persists independent of the temporary changes in cAMP concentration which can be induced by pharmacological agents.

引用

页码：1004 / 1010

页数：7

共 26 条

[11]

HAMILTON DL, 1978, CAN J COMP MED, V42, P327

[12]

HAMILTON DL, 1977, CAN J COMP MED, V41, P306

[13]

HUANG YC, 1971, BIOCHEMISTRY-US, V10, P2278

[14]

KAPITANY RA, INFECT IMMUN