Phosphorylation of RNAPII To P-TEFb or not to P-TEFb?

被引：44

作者：

Bartkowiak, Bartlomiej ^{[1
]}

Greenleaf, Arno L. ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Biochem, Duke Ctr RNA Biol, Durham, NC 27710 USA

来源：

TRANSCRIPTION-AUSTIN | 2011年 / 2卷 / 03期

关键词：

transcription; RNA polymerase II; CTD kinase; C-terminal repeat domain; P-TEFb; CDK12; CDK13;

D O I：

10.4161/trns.2.3.15004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The C-terminal domain of RNA poly II undergoes a cycle of phosphorylation which allows it to temporally couple transcription with transcription associated processes. The characterization of hitherto unrecognized metazoan elongation phase CTD kinase activities expands our understanding of this coupling. We discuss the circumstances that delayed the recognition of these kinase activities.

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页码：115 / 119

页数：5

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