STEROL MOLECULE - STRUCTURE, BIOSYNTHESIS, AND FUNCTION

被引:200
作者
BLOCH, K
机构
关键词
STEROLS; CHOLESTEROL; BIOLOGIC SYNTHESIS; HISTORY OF CHEMICAL STRUCTURE;
D O I
10.1016/0039-128X(92)90081-J
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
This review briefly summarizes key researches on the structure of the sterol molecule from its very beginnings to the definitive elucidation in 1932. Cholesterol biosynthesis treated in somewhat greater detail covers the period from the 1930s to the 1960s. As a historic contribution, it presents researches previously published in numerous books, reviews, and original papers. The selection of topics, dictated by limits of time and space, is necessarily arbitrary and a personal choice. Readers of this journal will be familiar with the relevant chemical structures. Structural formulas are therefore omitted.
引用
收藏
页码:378 / 383
页数:6
相关论文
共 44 条
[31]  
ROSENHEIM A, 1932, CHEM IND, V51, P464
[32]  
RUDNEY H, 1959, CIBA F S BIOSYNTHESI, P75
[33]   THE ISOPRENE RULE AND THE BIOGENESIS OF TERPENIC COMPOUNDS [J].
RUZICKA, L .
EXPERIENTIA, 1953, 9 (10) :357-367
[34]   THE STEREOCHEMISTRY OF POLYENE CYCLIZATION [J].
STORK, G ;
BURGSTAHLER, AW .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1955, 77 (19) :5068-5077
[35]   THE UTILIZATION OF BETA-HYDROXY-BETA-METHYL-SIGMA-VALEROLACTONE IN CHOLESTEROL BIOSYNTHESIS [J].
TAVORMINA, PA ;
GIBBS, MH ;
HUFF, JW .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1956, 78 (17) :4498-4499
[36]   ON THE FORMATION OF A PHOSPHORYLATED DERIVATIVE OF MEVALONIC ACID [J].
TCHEN, TT .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1957, 79 (23) :6344-6345
[37]   ZUR KENNTNIS DER TRITERPENE .175. EIN NEUER WEG ZUR OFFNUNG DES RINGES-C BEIM LANOSTADIENOL [J].
VOSER, W ;
GUNTHARD, HH ;
HEUSSER, H ;
JEGER, O ;
RUZICKA, L .
HELVETICA CHIMICA ACTA, 1952, 35 (06) :2065-2072
[38]   *ZUR KENNTNIS DER TRITERPENE .170. UBER DIE HERSTELLUNG EINES WEITEREN RING-D-KETONS AUS LANOSTADIENOL [J].
VOSER, W ;
JEGER, O ;
RUZICKA, L .
HELVETICA CHIMICA ACTA, 1952, 35 (02) :503-510
[39]   ISOLATION AND SYNTHESIS OF A NEW STEROL FROM RAT FECES [J].
WELLS, WW ;
NEIDERHISER, DH .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1957, 79 (24) :6569-6570
[40]  
WIELAND H, 1932, Z PHYSL CHEM, V210, P261