INHIBITION OF INDUCED LYMPHOCYTE-PROLIFERATION BY LIPID AND PROTEIN-COMPONENTS OF THE SYNCYTIOTROPHOBLAST PLASMA-MEMBRANE

被引：4

作者：

GIRARD, ACL ^{[1
]}

GUILLAUMIN, JM ^{[1
]}

THIBAULT, G ^{[1
]}

RUPIN, A ^{[1
]}

DERUSSE, J ^{[1
]}

BARDOS, P ^{[1
]}

机构：

[1] FAC MED TOURS,IMMUNOL LAB,F-37032 TOURS,FRANCE

来源：

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 1995年 / 33卷 / 02期

关键词：

SYNCYTIOTROPHOBLAST PLASMA MEMBRANE; MEMBRANE LIPIDS; MEMBRANE PROTEINS; LYMPHOCYTE PROLIFERATION;

D O I：

10.1111/j.1600-0897.1995.tb00883.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

PROBLEM: The aim of this work was to define the respective responsibilities of the lipid and protein components of syncytiotrophoblast plasma membranes on the inhibition of lymphocyte proliferation induced in vitro. METHOD: A fractionation method using octyl-beta-D-glucopyranoside enabled lipoprotein, lipid, and protein fractions to be isolated from the membrane. RESULTS: The lipid fraction was shown nonspecifically to inhibit lymphocyte proliferation, to a lower extent compared with the native membrane. Alternatively, the protein fraction used as a proteoliposome contained the totality of the cytostatic effect of the native fraction. CONCLUSION: These results are discussed generally in the context of the immunoregulatory role of membrane lipids and proteins and in relation to the local properties of syncytiotrophoblast plasma membrane components in fetal graft tolerance.

引用

页码：182 / 189

页数：8

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