EFFECTS OF INDOMETHACIN ON CEREBRAL HEMODYNAMICS IN VERY PRETERM INFANTS

被引：205

作者：

EDWARDS, AD ^{[1
]}

WYATT, JS ^{[1
]}

RICHARDSON, C ^{[1
]}

POTTER, A ^{[1
]}

COPE, M ^{[1
]}

DELPY, DT ^{[1
]}

REYNOLDS, EOR ^{[1
]}

机构：

[1] UNIV COLL & MIDDLESEX SCH MED,DEPT MED PHYS & BIOENGN,LONDON,ENGLAND

来源：

LANCET | 1990年 / 335卷 / 8704期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/0140-6736(90)93030-S

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Near infrared spectroscopy was used to investigate the effects of intravenously administered indomethacin (0·1-0·2 mg/kg) on cerebral haemodynamics and oxygen delivery in 13 very preterm infants treated for patent ductus arteriosus. 7 infants received indomethacin by rapid injection (30 s) and 6 by slow infusion (20-30 min). In all the infants cerebral blood flow, oxygen delivery, blood volume, and the reactivity of blood volume to changes in arterial carbon dioxide tension fell sharply after indomethacin. There were no differences in the effects of rapid and slow infusion. These falls in cerebral oxygen delivery and the disruption of cerebrovascular control might compromise cellular oxygen availability, particularly in regions of the brain where the arterial supply is precarious. Care should be taken to ensure that oxygen delivery is optimum before the administration of indomethacin to preterm infants. © 1990.

引用

页码：1491 / 1495

页数：5

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