A NOVEL CHIRAL AUXILIARY FROM CHIRAL SPIRANES - CIS,CIS-(+) AND (-)-SPIRO[4.4]NONANE-1,6-DIOL AS CHIRAL MODIFIER IN LITHIUM ALUMINUM-HYDRIDE REDUCTION OF PHENYL ALKYL KETONES

被引：83

作者：

SRIVASTAVA, N ^{[1
]}

MITAL, A ^{[1
]}

KUMAR, A ^{[1
]}

机构：

[1] CENT DRUG RES INST,DIV PROC DEV,LUCKNOW 226001,UTTAR PRADESH,INDIA

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1992年 / 06期

关键词：

D O I：

10.1039/c39920000493

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

LiAlH4 reduction of phenyl alkyl ketones employing the hitherto unexplored chiral auxiliary cis, cis-(+)- and (-)-spiro[4.4]nonane-1,6-diol as chiral modifier gives the corresponding alcohol in 85-90% e.e. (enantiomeric excess).

引用

页码：493 / 494

页数：2

共 16 条

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