STEREODIVERGENT SYNTHESIS OF BETA-AMINO-ALPHA-HYDROXYPHOSPHONIC ACID-DERIVATIVES BY LEWIS-ACID MEDIATED STEREOSELECTIVE HYDROPHOSPHONYLATION OF ALPHA-AMINO ALDEHYDES

被引：68

作者：

YOKOMATSU, T ^{[1
]}

YAMAGISHI, T ^{[1
]}

SHIBUYA, S ^{[1
]}

机构：

[1] TOKYO COLL PHARM,1432-1 HORINOUCHI,HACHIOJI,TOKYO 19203,JAPAN

来源：

TETRAHEDRON-ASYMMETRY | 1993年 / 4卷 / 07期

关键词：

D O I：

10.1016/S0957-4166(00)80325-0

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The highly diastereoselective synthesis of beta-amino-alpha-hydroxyphosphonic acid derivatives was achieved by Lewis acid mediated hydrophosphonylation of alpha-dibenzylamino aldehyde. Diastereofacial differentiation could be controlled in either a chelation or a nonchelation manner by simple tuning of the nature of phosphoric nucleophiles.

引用

页码：1401 / 1404

页数：4

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