CHARACTERIZATION OF 3 RIFAMYCINS VIA ELECTROSPRAY MASS-SPECTROMETRY AND HPLC THERMOSPRAY MASS-SPECTROMETRY

被引：16

作者：

KORFMACHER, WA

BLOOM, J

CHURCHWELL, MI

GETEK, TA

HANSEN, EB

HOLDER, CL

MCMANUS, KT

机构：

[1] US FDA,NATL CTR TOXICOL RES,JEFFERSON,AR 72079

[2] TEXMS,HOUSTON,TX 77060

来源：

JOURNAL OF CHROMATOGRAPHIC SCIENCE | 1993年 / 31卷 / 12期

关键词：

D O I：

10.1093/chromsci/31.12.498

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Rifamycins are a class of antibiotic compounds of which rifampicin is the most commonly prescribed. Conventional electron-impact mass spectrometry of rifampicin has not been found to provide useful data. Thermospray and electrospray mass spectrometry are studied as potential tools for the analysis of rifampicin, rifamycin SV, and rifamycin B. Using thermospray and electrospray ionization, all three compounds provide significant ion intensity for either the [MH]+ or [MNa]+ ions. In addition, combined high-performance liquid chromatography—thermospray mass spectrometry provides useful analytical data for a mixture of the three rifamycins. © 1993 OUP Publishing Ltd.

引用

收藏

页码：498 / 501

页数：4

相关论文

共 20 条

[1] THERMOSPRAY INTERFACE FOR LIQUID-CHROMATOGRAPHY MASS-SPECTROMETRY [J].

BLAKLEY, CR ;

VESTAL, ML .

ANALYTICAL CHEMISTRY, 1983, 55 (04) :750-754

[2] MASS-SPECTRAL CHARACTERIZATION OF 3 ANTHRACYCLINE ANTIBIOTICS - A COMPARISON OF THERMOSPRAY MASS-SPECTROMETRY TO PARTICLE BEAM MASS-SPECTROMETRY [J].

BLOOM, J ;

LEHMAN, P ;

ISRAEL, M ;

ROSARIO, O ;

KORFMACHER, WA .

JOURNAL OF ANALYTICAL TOXICOLOGY, 1992, 16 (04) :223-227

[3]

Covey T R, 1988, Rapid Commun Mass Spectrom, V2, P249, DOI 10.1002/rcm.1290021111

[4]

GETEK TA, 1991, ORG MASS SPECTROM, V26, P697

[5] APPLICATION OF HPLC-THERMOSPRAY IONIZATION MASS-SPECTROMETRY FOR THE ANALYSIS OF TRIPROLIDINE AND ITS METABOLITE HYDROXYMETHYLTRIPROLIDINE IN BIOLOGICAL SAMPLES [J].

HANSEN, EB ;

GETEK, TA ;

KORFMACHER, WA .

JOURNAL OF ANALYTICAL TOXICOLOGY, 1989, 13 (03) :185-187

[6] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY THERMOSPRAY MASS-SPECTROMETRY OF GIBBERELLINS [J].

HANSEN, EB ;

ABIAN, J ;

GETEK, TA ;

CHOINSKI, JS ;

KORFMACHER, WA .

JOURNAL OF CHROMATOGRAPHY, 1992, 603 (1-2) :157-164

[7] DETERMINATION OF RIFAMPICIN AND ITS MAIN METABOLITES IN HUMAN-PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

ISHII, M ;

OGATA, H .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1988, 426 (02) :412-416

[8] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ASSAY OF RIFAMPICIN IN HUMAN SERUM [J].

JAMALUDDIN, ABM ;

SARWAR, G ;

RAHIM, MA ;

RAHMAN, MK .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1990, 525 (02) :495-497

[9] IDENTIFICATION OF 2 GLUCURONIDE METABOLITES OF DOXYLAMINE VIA THERMOSPRAY MASS-SPECTROMETRY AND THERMOSPRAY MASS-SPECTROMETRY MASS-SPECTROMETRY [J].

KORFMACHER, WA ;

HOLDER, CL ;

BETOWSKI, LD ;

MITCHUM, RK .

JOURNAL OF ANALYTICAL TOXICOLOGY, 1987, 11 (04) :182-184

[10] CHARACTERIZATION OF DOXYLAMINE AND PYRILAMINE METABOLITES VIA THERMOSPRAY MASS-SPECTROMETRY AND TANDEM MASS-SPECTROMETRY [J].

KORFMACHER, WA ;

HOLDER, CL ;

BETOWSKI, LD ;

MITCHUM, RK .

BIOMEDICAL AND ENVIRONMENTAL MASS SPECTROMETRY, 1988, 15 (09) :501-508