CHARACTERIZATION OF 3 RIFAMYCINS VIA ELECTROSPRAY MASS-SPECTROMETRY AND HPLC THERMOSPRAY MASS-SPECTROMETRY

被引：16

作者：

KORFMACHER, WA

BLOOM, J

CHURCHWELL, MI

GETEK, TA

HANSEN, EB

HOLDER, CL

MCMANUS, KT

机构：

[1] US FDA,NATL CTR TOXICOL RES,JEFFERSON,AR 72079

[2] TEXMS,HOUSTON,TX 77060

来源：

JOURNAL OF CHROMATOGRAPHIC SCIENCE | 1993年 / 31卷 / 12期

关键词：

D O I：

10.1093/chromsci/31.12.498

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Rifamycins are a class of antibiotic compounds of which rifampicin is the most commonly prescribed. Conventional electron-impact mass spectrometry of rifampicin has not been found to provide useful data. Thermospray and electrospray mass spectrometry are studied as potential tools for the analysis of rifampicin, rifamycin SV, and rifamycin B. Using thermospray and electrospray ionization, all three compounds provide significant ion intensity for either the [MH]+ or [MNa]+ ions. In addition, combined high-performance liquid chromatography—thermospray mass spectrometry provides useful analytical data for a mixture of the three rifamycins. © 1993 OUP Publishing Ltd.

引用

收藏

页码：498 / 501

页数：4

相关论文

共 20 条

[11] CHARACTERIZATION OF THE MYCOTOXIN FUMONISIN-B1 - COMPARISON OF THERMOSPRAY, FAST-ATOM-BOMBARDMENT AND ELECTROSPRAY MASS-SPECTROMETRY [J].

KORFMACHER, WA ;

CHIARELLI, MP ;

LAY, JO ;

BLOOM, J ;

HOLCOMB, M ;

MCMANUS, KT .

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 1991, 5 (10) :463-468

[12] CHARACTERIZATION OF THE ANTIHISTAMINES TRIPELENNAMINE, METHAPYRILENE, AND THENYLDIAMINE AND THEIR N-OXIDES BY THERMOSPRAY MASS-SPECTROMETRY [J].

KORFMACHER, WA ;

FREEMAN, JP ;

HANSEN, EB ;

HOLDER, CL ;

GETEK, TA .

JOURNAL OF ANALYTICAL TOXICOLOGY, 1989, 13 (02) :94-96

[13]

Lay J O Jr, 1989, Rapid Commun Mass Spectrom, V3, P72, DOI 10.1002/rcm.1290030306

[14] ELECTROSPRAY - ITS POTENTIAL AND LIMITATIONS AS AN IONIZATION METHOD FOR BIOMOLECULES [J].

MANN, M .

ORGANIC MASS SPECTROMETRY, 1990, 25 (11) :575-587

[15] NEW DEVELOPMENTS IN BIOCHEMICAL MASS-SPECTROMETRY - ELECTROSPRAY IONIZATION [J].

SMITH, RD ;

LOO, JA ;

EDMONDS, CG ;

BARINAGA, CJ ;

UDSETH, HR .

ANALYTICAL CHEMISTRY, 1990, 62 (09) :882-899

[16] AUTOMATED HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC METHOD FOR THE DETERMINATION OF RIFAMPICIN IN PLASMA [J].

SWART, KJ ;

PAPGIS, M .

JOURNAL OF CHROMATOGRAPHY, 1992, 593 (1-2) :21-24

[17] COMPARISON OF MASS-SPECTROMETRIC METHODS FOR STUDYING THERMALLY LABILE COMPOUNDS - RIFAPENTINE [J].

VEKEY, K ;

EDWARDS, DMF ;

ZERILLI, LF ;

MAK, M ;

TAMAS, J ;

RAVERDINO, V ;

SELVA, A .

ORGANIC MASS SPECTROMETRY, 1990, 25 (09) :465-474

[18] LIQUID-CHROMATOGRAPHIC MASS-SPECTROMETRIC STUDIES ON RIFAMYCIN ANTIBIOTICS [J].

VEKEY, K ;

EDWARDS, DMF ;

ZERILLI, LF .

JOURNAL OF CHROMATOGRAPHY, 1989, 474 (01) :317-327

[19] LIQUID-CHROMATOGRAPHIC ASSAY FOR THE SIMULTANEOUS DETERMINATION OF PYRAZINAMIDE AND RIFAMPICIN IN SERUM SAMPLES FROM PATIENTS WITH TUBERCULOUS MENINGITIS [J].

WOO, J ;

WONG, CL ;

TEOH, R ;

CHAN, K .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1987, 420 (01) :73-80

[20] FIELD DESORPTION MASS-SPECTRA OF RIFAMYCINS [J].

ZERILLI, LF ;

LANDI, M ;

GALLO, GG ;

MAURER, KH ;

RAPP, U .

BIOMEDICAL MASS SPECTROMETRY, 1975, 2 (06) :307-312