CONTROL OF SIGNAL-TRANSDUCTION AND MORPHOGENESIS BY RAS

被引：35

作者：

HUGHES, DA

机构：

[1] CRC Centre for Cell and Molecular Biology, Chester Beatty Laboratories, Institute for Cancer Research, London

来源：

SEMINARS IN CELL BIOLOGY | 1995年 / 6卷 / 02期

关键词：

CELL POLARITY; FISSION YEAST; MAP KINASE; MATING; RAS;

D O I：

10.1016/1043-4682(95)90005-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The single Ras homologue (Ras1) of S. pombe regulates two distinct processes: (1) Signal transduction through a MAP kinase-like protein kinase cascade in response to mating pheromones. In this pathway Ras1 interacts with the protein kinase Byr2 and leads to its activation in conjunction with a signal from the receptor-coupled, heterotrimeric G protein. (2) Polarized cell growth both during the cell cycle and during directed cell extension towards a mating partner. Ras1 interacts with Ral1/Scd1, a putative guanine-nucleotide-exchange factor, which could activate Cdc42, Rho-like GTP-binding protein. Cdc42 may regulate the dynamics of the actin cytoskeleton.

引用

页码：89 / 94

页数：6

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