COMPARISON OF CHANGES IN ATROPINE-INDUCED TACHYCARDIA AND ATROPINE CONCENTRATION IN CONSCIOUS DOGS

被引：21

作者：

CHASSAING, C ^{[1
]}

GODENECHE, D ^{[1
]}

BOUCHER, M ^{[1
]}

DUCHENEMARULLAZ, P ^{[1
]}

机构：

[1] INSERM,U71,UNITE RECH,F-63000 CLERMONT FERRAND,FRANCE

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 58卷 / 04期

关键词：

Atropine-induced tachycardia; Blockade of sympathetic system; Blood atropine concentration; Conscious dog; Heart rate;

D O I：

10.1016/0014-2999(79)90314-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In the conscious dog, after intravenous injection of 0.2 mg/kg 3H-labelled atropine the progressive decreases of the heart rate was well correlated with the disappearance of atropine from the blood. But, with atropine infusion (0.2 mg/kg/h) the tachycardia decreased progressively in spite of an increase in blood concentration of atropine. Differences appeared between the normal animals of those pretreated with propanolol or reserpine, and the animals which had undergone bilateral thoracic sympathectomy. In the stellectomized animals atropine induced a smaller but much more lasting cardiac acceleration than under the other experimental conditions. It seems that only peripheral factors are involved in the complex interactions between the adrenergic and cholinergic nervous systems at the sinus node level. © 1979.

引用

页码：433 / 441

页数：9