ABNORMALITIES IN ADRENAL ANDROGENS, BUT NOT OF GLUCOCORTICOIDS, IN EARLY ALZHEIMERS-DISEASE

被引:35
作者
NASMAN, B
OLSSON, T
SECKL, JR
ERIKSSON, S
VIITANEN, M
BUCHT, G
CARLSTROM, K
机构
[1] UMEA UNIV,HOSP NO SWEDEN,DEPT INTERNAL MED,S-90185 UMEA,SWEDEN
[2] WESTERN GEN HOSP,DEPT MED,EDINBURGH EH4 2XU,MIDLOTHIAN,SCOTLAND
[3] HUDDINGE UNIV HOSP,KAROLINSKA INST,DEPT GERIATR MED,S-14186 HUDDINGE,SWEDEN
[4] HUDDINGE UNIV HOSP,KAROLINSKA INST,DEPT OBSTET & GYNAECOL,S-14186 HUDDINGE,SWEDEN
关键词
ALZHEIMERS DISEASE; CORTISOL; ADRENOCORTICOTROPIN; ADRENAL ANDROGENS;
D O I
10.1016/0306-4530(94)E0044-A
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In an attempt to evaluate possible adrenal abnormalities in Alzheimer's disease (AD), prestimulus levels and ACTH-stimulated serum levels of steroid hormones, corticosteroid-binding globulin (CBG), and insulin-like growth factor I (IGF-I) were measured in 18 patients with early AD (8 men, 10 women; 74.6 +/- 6.5 years, mean +/- SD) and 19 healthy controls (10 men, 9 women; 74.2 +/- 7.6 years, mean +/- SD). Steroid hormone levels were measured before and after an intravenous bolus injection of 250 mu g ACTH. AD per se had an independent influence on hormone levels when evaluated in MANOVA models. AD patients had significantly higher prestimulus levels of dehydroepiandrosterone and androstenedione (p = .04 and p = .003, respectively) with accentuated differences after ACTH (p = .02 and p < .001 for peak responses, respectively). Serum levels of cortisol, CBG, free cortisol, 17 alpha-hydroxyprogesterone (17 alpha-OHP), and IGF-I did not differ between groups. These abnormalities may have implications for neuronal degeneration as well as for behavioural symptoms in AD.
引用
收藏
页码:83 / 94
页数:12
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