RING-D OXYGENATED SPIROLACTONES - CHARACTERIZATION OF A HUMAN METABOLIC PRODUCT OF SPIRONOLACTONE

被引:1
作者
CHINN, LJ
BROWN, EA
MIZUBA, SS
KARIM, A
机构
[1] GD SEARLE & CO,DEPT CHEM,CHICAGO,IL 60680
[2] GD SEARLE & CO,DEPT BIOL RES,CHICAGO,IL 60680
[3] GD SEARLE & CO,DEPT DRUG METAB & RADIOCHEM,CHICAGO,IL 60680
关键词
D O I
10.1021/jm00213a008
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:352 / 355
页数:4
相关论文
共 15 条
[1]   THE DEHYDROGENATION OF CORTICOSTEROIDS WITH CHLORANIL [J].
AGNELLO, EJ ;
LAUBACH, GD .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1960, 82 (16) :4293-4299
[2]  
BEARD CC, 1972, ORGANIC REACTIONS ST, V1, P265
[3]   STEROIDAL ALDOSTERONE BLOCKERS .2. [J].
CELLA, JA ;
TWEIT, RC .
JOURNAL OF ORGANIC CHEMISTRY, 1959, 24 (08) :1109-1110
[4]   3-(16BETA,17BETA-DIHYDROXY-3-OXOANDROST-4-EN-17 ALPHA-YL)PROPIONIC ACID GAMMA-LACTONE, ITS PREPARATION AND ANTIMINERALOCORTICOID ACTIVITY [J].
CHINN, LJ ;
HOFMANN, LM .
JOURNAL OF MEDICINAL CHEMISTRY, 1973, 16 (07) :839-843
[5]   SYNTHESIS OF 15-KETO-6-BETA,7-BETA-METHYLENEPROGESTERONE - EFFECT OF 6-BETA,7-BETA-METHYLENE GROUP ON MINERALOCORTICOID ACTIVITY [J].
CHINN, LJ ;
DESAI, BN .
JOURNAL OF MEDICINAL CHEMISTRY, 1975, 18 (03) :268-271
[6]  
DRYDEN HL, 1966, Patent No. 3270008
[7]  
HOFMANN LM, 1975, J PHARMACOL EXP THER, V194, P450
[8]  
HOFMANN LM, 1974, RECENT ADV RENAL PHY, P305
[9]  
JIU J, 1974, DEV IND MICROBIOL, V15, P345
[10]   ACTION OF NEW STEROIDS IN BLOCKING EFFECTS OF ALDOSTERONE AND DEOXYCORTICOSTERONE ON SALT [J].
KAGAWA, CM ;
CELLA, JA ;
VANARMAN, CG .
SCIENCE, 1957, 126 (3281) :1015-1016