SURFACE MODIFICATION OF POLYMERS .5. BIOMATERIAL APPLICATIONS

被引：62

作者：

ALLMER, K ^{[1
]}

HILBORN, J ^{[1
]}

LARSSON, PH ^{[1
]}

HULT, A ^{[1
]}

RANBY, B ^{[1
]}

机构：

[1] ROYAL INST TECHNOL,DEPT POLYMER TECHNOL,S-10044 STOCKHOLM 70,SWEDEN

来源：

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY | 1990年 / 28卷 / 01期

关键词：

D O I：

10.1002/pola.1990.080280112

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Polyethylene films were surface grafted with glycidyl methacrylate (GMA) by UV irradiating the film for 5 min together with benzophenone. Poly(ethylene glycol) (PEG) was attached to the grafted surface through reaction with the epoxy groups. This yielded a surface which consisted of 95% PEG as measured with ESCA. The adsorption of human transferrin onto this film was significantly reduced as compared with a pure polyethylene film. Heparin was also reacted with a GMA grafted PE surface. ESCA showed that heparin was grafted to the surface, and in vitro blood clotting tests on the heparinized PE surface showed a reduced thrombus formation. GMA grafted polystyrene wells were reacted with carbohydrazide, to the formed carbohydrazide surface a rabbit antibody raised against mouse urinary protein (RaMUP) was covalently coupled. The RaMUP coupled surfaces was used in the detection of mouse urinary protein (MUP) at low concentrations (ca. 1 ng/mL) with an ELISA technique. Copyright © 1990 John Wiley & Sons, Inc.

引用

页码：173 / 183

页数：11