GEPIRONE AND 1-(2-PYRIMIDINYL)-PIPERAZINE-INDUCED REDUCTION OF AVERSIVELY EVOKED ULTRASONIC VOCALIZATION IN THE RAT

被引:19
作者
CULLEN, WK [1 ]
ROWAN, MJ [1 ]
机构
[1] UNIV DUBLIN TRINITY COLL,DEPT PHARMACOL & THERAPEUT,DUBLIN 2,IRELAND
关键词
GEPIRONE; 1-(2-PYRIMIDINYL)-PIPERAZINE; PROADIFEN; ULTRASONIC VOCALIZATION PASSIVE AVOIDANCE; RAT;
D O I
10.1016/0091-3057(94)90531-2
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Ultrasonic (22 kHz) vocalisation in response to a mildly aversive foot shock was measured in the dark compartment of a light-dark box both immediately and 24 h after the shock. Gepirone (1 and 5 mg/kg, IP) produced a reduction in the duration of vocalisation at both times. Although a metabolic inhibitor, proadifen (40 mg/kg) did not reduce this effect of gepirone, the gepirone hepatic metabolite, 1-(2-pyrimidinyl)-piperazine (1-PP, 1 mg/kg), was also active in the test. Performance of a 24 h step-through passive avoidance task was impaired by gepirone only at a dose, 5 mg/kg, which also reduced spontaneous locomotor and rearing activity in the apparatus. It would appear that mild foot shock-evoked ultrasonic vocalisation may provide a more sensitive indicator of the effect of gepirone and related drugs on the affective response of rats to aversive stimulation.
引用
收藏
页码:301 / 306
页数:6
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