NICOTINIC ACETYLCHOLINE-RECEPTORS ON THE SURFACE OF THE BLOOD FLUKE SCHISTOSOMA

被引：36

作者：

CAMACHO, M ^{[1
]}

ALSFORD, S ^{[1
]}

JONES, A ^{[1
]}

AGNEW, A ^{[1
]}

机构：

[1] UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED,WELLCOME RES CTR PARASIT INFECT,DEPT BIOL,LONDON SW7 2BB,ENGLAND

来源：

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 1995年 / 71卷 / 01期

基金：

英国惠康基金;

关键词：

SCHISTOSOMA; ACETYLCHOLINESTERASE; NICOTINIC ACETYLCHOLINE RECEPTOR; ALPHA-BUNGAROTOXIN; TEGUMENT;

D O I：

10.1016/0166-6851(94)00039-P

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Blood dwelling stages of schistosomes have acetylcholinesterase (AChE) on their teguments. As an initial step towards understanding the function of tegumental AChE, we have used specific ligand-binding assays to identify nicotinic acetylcholine receptors (nAChR) on the schistosome surface. AChR could not be detected on migratory stages using fluoroscein isothiocyanate-alpha-bungarotoxin binding but the amount of specific labelling increased on sexual pairing and as the parasites matured into egg-producing adults. Both AChE and nAChR were concentrated on the dorsal surface of the adult male. These results indicate a role for AChE and AChR associated with the transporting function of this membrane.

引用

页码：127 / 134

页数：8

共 38 条

[1] MEMBRANE-TRANSPORT IN SCHISTOSOMA-MANSONI - TRANSPORT OF AMINO-ACIDS BY ADULT MALES [J].