SYNTHESIS AND FLUORESCENT PROPERTIES OF A NEW PHOTOSTABLE THIOL REAGENT BACM

被引：22

作者：

CHAURASIA, CS ^{[1
]}

KAUFFMAN, JM ^{[1
]}

机构：

[1] PHILADELPHIA COLL PHARM & SCI,DEPT CHEM,PHILADELPHIA,PA 19104

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1990年 / 27卷 / 03期

关键词：

D O I：

10.1002/jhet.5570270347

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The 3‐maleimidocoumarin BACM (2d) is a new tag designed to react with thiols in biological materials to form fluorescent derivatives whose emission is in the 500 nm (green) region with good resistance to fading. The fluorescence properties of its N‐acetyl‐L‐cysteine derivative are described. BACM itself is non‐fluorescent, as is its predecessor, DACM (1a). A synthesis of BACM is reported which avoids the formation of nitrocoumarin isomers obtained in the reported synthesis of DACM. The synthesis of the related 3‐(4‐maleimidophenyl)coumarin is also described. Copyright © 1990 Journal of Heterocyclic Chemistry

引用

页码：727 / 733

页数：7

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