EFFICIENT INCORPORATION OF HUMAN CD4 PROTEIN INTO AVIAN-LEUKOSIS VIRUS-PARTICLES

被引：85

作者：

YOUNG, JAT ^{[1
]}

BATES, P ^{[1
]}

WILLERT, K ^{[1
]}

VARMUS, HE ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO,SCH MED,DEPT BIOCHEM & BIOPHYS,SAN FRANCISCO,CA 94143

来源：

SCIENCE | 1990年 / 250卷 / 4986期

关键词：

D O I：

10.1126/science.2175047

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Virus envelope (Env) proteins are thought to contain specific signals for selective uptake by virus particles. In the course of attempting to define these signals by testing virus incorporation of CD4-Env chimeric proteins, normal human CD4 was found to be efficiently and selectively assembled into avian leukosis virus particles in quail cells. Viruses bearing CD4 at their surface may be useful reagents in the design of retrovirus-mediated gene therapy for the acquired immune deficiency syndrome.

引用

页码：1421 / 1423

页数：3

共 25 条

[1]

BATES P, UNPUB

[2] INTRACELLULAR PRECURSORS TO MAJOR GLYCOPROTEIN OF AVIAN ONCOVIRUSES IN CHICKEN-EMBRYO FIBROBLASTS [J].

BUCHHAGEN, DL ;

HANAFUSA, H .

JOURNAL OF VIROLOGY, 1978, 25 (03) :845-851

[3] SPECIFIC SELECTION OF HOST-CELL GLYCOPROTEINS DURING ASSEMBLY OF MURINE LEUKEMIA-VIRUS AND VESICULAR STOMATITIS-VIRUS - PRESENCE OF THY-1 GLYCOPROTEIN AND ABSENCE OF H-2, PGP-1 AND T-200 GLYCOPROTEINS ON THE ENVELOPES OF THESE VIRUS-PARTICLES [J].

CALAFAT, J ;

JANSSEN, H ;

DEMANT, P ;

HILGERS, J ;

ZAVADA, J .

JOURNAL OF GENERAL VIROLOGY, 1983, 64 (JUN) :1241-1253

[4] AVIAN-SARCOMA VIRUS GAG AND ENV GENE STRUCTURAL PROTEIN PRECURSORS CONTAIN A COMMON AMINO-TERMINAL SEQUENCE [J].

FICHT, TA ;

CHANG, LJ ;

STOLTZFUS, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (02) :362-366

[5] ABORTIVE INFECTION OF JAPANESE-QUAIL CELLS WITH AVIAN SARCOMA VIRUSES [J].

FRIIS, RR .

VIROLOGY, 1972, 50 (03) :701-712

[6] ROUS-SARCOMA VIRUS-P19 AND VIRUS-GP35 CAN BE CHEMICALLY CROSSLINKED O HIGH MOLECULAR-WEIGHT COMPLEXES - AN INSIGHT INTO VIRUS ASSEMBLY [J].

GEBHARDT, A ;

BOSCH, JV ;

ZIEMIECKI, A ;

FRIIS, RR .

JOURNAL OF MOLECULAR BIOLOGY, 1984, 174 (02) :297-317

[7] MUTATIONAL ANALYSIS OF HIV-1 TAT MINIMAL DOMAIN PEPTIDES - IDENTIFICATION OF TRANS-DOMINANT MUTANTS THAT SUPPRESS HIV-LTR-DRIVEN GENE-EXPRESSION [J].

GREEN, M ;

ISHINO, M ;

LOEWENSTEIN, PM .

CELL, 1989, 58 (01) :215-223

[8]

*HARLOW E, 1988, ANTIBODIES LABORATOR

[9] ADAPTER PLASMIDS SIMPLIFY THE INSERTION OF FOREIGN DNA INTO HELPER-INDEPENDENT RETROVIRAL VECTORS [J].

HUGHES, SH ;

GREENHOUSE, JJ ;

PETROPOULOS, CJ ;

SUTRAVE, P .

JOURNAL OF VIROLOGY, 1987, 61 (10) :3004-3012

[10] ASSEMBLY OF GAG-BETA-GALACTOSIDASE PROTEINS INTO RETROVIRUS PARTICLES [J].

JONES, TA ;

BLAUG, G ;

HANSEN, M ;

BARKLIS, E .

JOURNAL OF VIROLOGY, 1990, 64 (05) :2265-2279

← 1 2 3 →