EFFICIENT INCORPORATION OF HUMAN CD4 PROTEIN INTO AVIAN-LEUKOSIS VIRUS-PARTICLES

被引：85

作者：

YOUNG, JAT ^{[1
]}

BATES, P ^{[1
]}

WILLERT, K ^{[1
]}

VARMUS, HE ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO,SCH MED,DEPT BIOCHEM & BIOPHYS,SAN FRANCISCO,CA 94143

来源：

SCIENCE | 1990年 / 250卷 / 4986期

关键词：

D O I：

10.1126/science.2175047

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Virus envelope (Env) proteins are thought to contain specific signals for selective uptake by virus particles. In the course of attempting to define these signals by testing virus incorporation of CD4-Env chimeric proteins, normal human CD4 was found to be efficiently and selectively assembled into avian leukosis virus particles in quail cells. Viruses bearing CD4 at their surface may be useful reagents in the design of retrovirus-mediated gene therapy for the acquired immune deficiency syndrome.

引用

页码：1421 / 1423

页数：3

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