THE FATE OF PROTEIN ANTIGEN IN EARTHWORMS - STUDY INVIVO

被引:9
作者
REJNEK, J
TUCKOVA, L
SIMA, P
BILEJ, M
机构
[1] Department of Immunology, Institute of Microbiology, Czech Academy of Sciences, Prague
关键词
LUMBRICUS-TERRESTRIS; EISENIA-FOETIDA; CELOMIC FLUID; CELOMOCYTE; FATE OF ANTIGEN; INVIVO; PROTEOLYSIS;
D O I
10.1016/0165-2478(93)90044-3
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Parenteral administration of antigen induces in the earthworms Lumbricus terrestris and Eisenia foetida the formation of antigen-binding protein. Labelled antigen was efficiently digested in the coelomic fluids of both species since the total amount of radioactivity in the coelomic fluids decreased. Antigen internalized in the free coelomocytes of both species was present in a TCA-precipitable form, although the decline of total radioactivity was higher than in the coelomic fluid, indicating that the TCA-nonprecipitable fragments are rapidly released from coelomocytes into the coelomic fluid. Within the first 24 h after administration, labelled antigen was detected throughout all tissues except for the epidermis and cuticle, and after 4 days it was found in the chloragogenic tissue around the gut, dorsal vein and typhlosole.
引用
收藏
页码:131 / 136
页数:6
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