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SUBSTITUTION OF ASPARTIC ACID-217 OF CITROBACTER-FREUNDII CEPHALOSPORINASE AND PROPERTIES OF THE MUTANT ENZYMES
被引:16
作者
:
TSUKAMOTO, K
论文数:
0
引用数:
0
h-index:
0
机构:
CHIBA UNIV,FAC PHARMACEUT SCI,DIV MICROBIAL CHEM,1-33 YAYOI CHO,CHIBA 260,JAPAN
CHIBA UNIV,FAC PHARMACEUT SCI,DIV MICROBIAL CHEM,1-33 YAYOI CHO,CHIBA 260,JAPAN
TSUKAMOTO, K
[
1
]
KIKURA, R
论文数:
0
引用数:
0
h-index:
0
机构:
CHIBA UNIV,FAC PHARMACEUT SCI,DIV MICROBIAL CHEM,1-33 YAYOI CHO,CHIBA 260,JAPAN
CHIBA UNIV,FAC PHARMACEUT SCI,DIV MICROBIAL CHEM,1-33 YAYOI CHO,CHIBA 260,JAPAN
KIKURA, R
[
1
]
OHNO, R
论文数:
0
引用数:
0
h-index:
0
机构:
CHIBA UNIV,FAC PHARMACEUT SCI,DIV MICROBIAL CHEM,1-33 YAYOI CHO,CHIBA 260,JAPAN
CHIBA UNIV,FAC PHARMACEUT SCI,DIV MICROBIAL CHEM,1-33 YAYOI CHO,CHIBA 260,JAPAN
OHNO, R
[
1
]
SAWAI, T
论文数:
0
引用数:
0
h-index:
0
机构:
CHIBA UNIV,FAC PHARMACEUT SCI,DIV MICROBIAL CHEM,1-33 YAYOI CHO,CHIBA 260,JAPAN
CHIBA UNIV,FAC PHARMACEUT SCI,DIV MICROBIAL CHEM,1-33 YAYOI CHO,CHIBA 260,JAPAN
SAWAI, T
[
1
]
机构
:
[1]
CHIBA UNIV,FAC PHARMACEUT SCI,DIV MICROBIAL CHEM,1-33 YAYOI CHO,CHIBA 260,JAPAN
来源
:
FEBS LETTERS
|
1990年
/ 264卷
/ 02期
关键词
:
Active site;
Cephalosporinase;
Citrobacter freundii;
Oxyimino-cephalosporin;
Site-directed mutagenesis;
β-Lactamase;
D O I
:
10.1016/0014-5793(90)80250-M
中图分类号
:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号
:
071010 ;
081704 ;
摘要
:
On the assumption that Asp-217 of a Citrobacter freundii cephalosporinase forms a salt-bridge with the conserved Lys-67, Asp-217 was changed to glutamic acid, threonine or lysine. The mutant enzymes retained about the same level of activity as that of the wild-type enzyme, and the participation of Asp-217 in the salt-bridge was ruled out. However, the mutations resulted in an increase in hydrolytic activity toward oxyimino-cephalosporins such as cefuroxime, cefmenoxime and ceftazidime, suggesting a possible mechanism of the bacterial resistance to the novel β-lactams by a single mutation in cephalosporinases. © 1990.
引用
收藏
页码:211 / 214
页数:4
相关论文
共 27 条
[11]
Miller J.H., 1972, EXPT MOL GENETICS, P1
[12]
MICRO-IODOMETRIC ASSAY FOR PENICILLINASE
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NOVICK, RP
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OCALLAGHAN, CH
论文数:
0
引用数:
0
h-index:
0
机构:
GLAXO RES LTD,GREENFORD UB6 OHE,MIDDLESEX,ENGLAND
GLAXO RES LTD,GREENFORD UB6 OHE,MIDDLESEX,ENGLAND
OCALLAGHAN, CH
SYKES, RB
论文数:
0
引用数:
0
h-index:
0
机构:
GLAXO RES LTD,GREENFORD UB6 OHE,MIDDLESEX,ENGLAND
GLAXO RES LTD,GREENFORD UB6 OHE,MIDDLESEX,ENGLAND
SYKES, RB
RYAN, DM
论文数:
0
引用数:
0
h-index:
0
机构:
GLAXO RES LTD,GREENFORD UB6 OHE,MIDDLESEX,ENGLAND
GLAXO RES LTD,GREENFORD UB6 OHE,MIDDLESEX,ENGLAND
RYAN, DM
FOORD, RD
论文数:
0
引用数:
0
h-index:
0
机构:
GLAXO RES LTD,GREENFORD UB6 OHE,MIDDLESEX,ENGLAND
GLAXO RES LTD,GREENFORD UB6 OHE,MIDDLESEX,ENGLAND
FOORD, RD
MUGGLETON, PW
论文数:
0
引用数:
0
h-index:
0
机构:
GLAXO RES LTD,GREENFORD UB6 OHE,MIDDLESEX,ENGLAND
GLAXO RES LTD,GREENFORD UB6 OHE,MIDDLESEX,ENGLAND
MUGGLETON, PW
[J].
JOURNAL OF ANTIBIOTICS,
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[14]
REFINED CRYSTAL-STRUCTURE OF BETA-LACTAMASE FROM CITROBACTER-FREUNDII INDICATES A MECHANISM FOR BETA-LACTAM HYDROLYSIS
OEFNER, C
论文数:
0
引用数:
0
h-index:
0
机构:
F HOFFMANN LA ROCHE & CO LTD, CENT RES UNIT, CH-4002 BASEL, SWITZERLAND
OEFNER, C
DARCY, A
论文数:
0
引用数:
0
h-index:
0
机构:
F HOFFMANN LA ROCHE & CO LTD, CENT RES UNIT, CH-4002 BASEL, SWITZERLAND
DARCY, A
DALY, JJ
论文数:
0
引用数:
0
h-index:
0
机构:
F HOFFMANN LA ROCHE & CO LTD, CENT RES UNIT, CH-4002 BASEL, SWITZERLAND
DALY, JJ
GUBERNATOR, K
论文数:
0
引用数:
0
h-index:
0
机构:
F HOFFMANN LA ROCHE & CO LTD, CENT RES UNIT, CH-4002 BASEL, SWITZERLAND
GUBERNATOR, K
CHARNAS, RL
论文数:
0
引用数:
0
h-index:
0
机构:
F HOFFMANN LA ROCHE & CO LTD, CENT RES UNIT, CH-4002 BASEL, SWITZERLAND
CHARNAS, RL
HEINZE, I
论文数:
0
引用数:
0
h-index:
0
机构:
F HOFFMANN LA ROCHE & CO LTD, CENT RES UNIT, CH-4002 BASEL, SWITZERLAND
HEINZE, I
HUBSCHWERLEN, C
论文数:
0
引用数:
0
h-index:
0
机构:
F HOFFMANN LA ROCHE & CO LTD, CENT RES UNIT, CH-4002 BASEL, SWITZERLAND
HUBSCHWERLEN, C
WINKLER, FK
论文数:
0
引用数:
0
h-index:
0
机构:
F HOFFMANN LA ROCHE & CO LTD, CENT RES UNIT, CH-4002 BASEL, SWITZERLAND
WINKLER, FK
[J].
NATURE,
1990,
343
(6255)
: 284
-
288
[15]
COMPARATIVE-STUDY OF 7 CEPHALOSPORINS - SUSCEPTIBILITY TO BETA-LACTAMASES AND ABILITY TO PENETRATE SURFACE-LAYERS OF ESCHERICHIA-COLI
RICHMOND, MH
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BRISTOL,DEPT BACTERIOL,BRISTOL BS8 1TD,GLOUCESTERSHIRE,ENGLAND
UNIV BRISTOL,DEPT BACTERIOL,BRISTOL BS8 1TD,GLOUCESTERSHIRE,ENGLAND
RICHMOND, MH
WOTTON, S
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BRISTOL,DEPT BACTERIOL,BRISTOL BS8 1TD,GLOUCESTERSHIRE,ENGLAND
UNIV BRISTOL,DEPT BACTERIOL,BRISTOL BS8 1TD,GLOUCESTERSHIRE,ENGLAND
WOTTON, S
[J].
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,
1976,
10
(02)
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-
222
[16]
DNA SEQUENCING WITH CHAIN-TERMINATING INHIBITORS
SANGER, F
论文数:
0
引用数:
0
h-index:
0
SANGER, F
NICKLEN, S
论文数:
0
引用数:
0
h-index:
0
NICKLEN, S
COULSON, AR
论文数:
0
引用数:
0
h-index:
0
COULSON, AR
[J].
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1977,
74
(12)
: 5463
-
5467
[17]
SAWAI T, 1988, REV INFECT DIS, V10, P721
[18]
A SET OF BACTERIAL STRAINS FOR EVALUATION OF BETA-LACTAMASE-STABILITY OF BETA-LACTAM ANTIBIOTICS
SAWAI, T
论文数:
0
引用数:
0
h-index:
0
SAWAI, T
YOSHIDA, T
论文数:
0
引用数:
0
h-index:
0
YOSHIDA, T
TSUKAMOTO, K
论文数:
0
引用数:
0
h-index:
0
TSUKAMOTO, K
YAMAGISHI, S
论文数:
0
引用数:
0
h-index:
0
YAMAGISHI, S
[J].
JOURNAL OF ANTIBIOTICS,
1981,
34
(10)
: 1318
-
1326
[19]
SAWAI T, 1982, J BACTERIOL, V152, P567
[20]
SIROT J, 1988, REV INFECT DIS, V10, P850
←
1
2
3
→
共 27 条
[11]
Miller J.H., 1972, EXPT MOL GENETICS, P1
[12]
MICRO-IODOMETRIC ASSAY FOR PENICILLINASE
NOVICK, RP
论文数:
0
引用数:
0
h-index:
0
NOVICK, RP
[J].
BIOCHEMICAL JOURNAL,
1962,
83
(02)
: 236
-
&
[13]
CEFUROXIME - NEW CEPHALOSPORIN ANTIBIOTIC
OCALLAGHAN, CH
论文数:
0
引用数:
0
h-index:
0
机构:
GLAXO RES LTD,GREENFORD UB6 OHE,MIDDLESEX,ENGLAND
GLAXO RES LTD,GREENFORD UB6 OHE,MIDDLESEX,ENGLAND
OCALLAGHAN, CH
SYKES, RB
论文数:
0
引用数:
0
h-index:
0
机构:
GLAXO RES LTD,GREENFORD UB6 OHE,MIDDLESEX,ENGLAND
GLAXO RES LTD,GREENFORD UB6 OHE,MIDDLESEX,ENGLAND
SYKES, RB
RYAN, DM
论文数:
0
引用数:
0
h-index:
0
机构:
GLAXO RES LTD,GREENFORD UB6 OHE,MIDDLESEX,ENGLAND
GLAXO RES LTD,GREENFORD UB6 OHE,MIDDLESEX,ENGLAND
RYAN, DM
FOORD, RD
论文数:
0
引用数:
0
h-index:
0
机构:
GLAXO RES LTD,GREENFORD UB6 OHE,MIDDLESEX,ENGLAND
GLAXO RES LTD,GREENFORD UB6 OHE,MIDDLESEX,ENGLAND
FOORD, RD
MUGGLETON, PW
论文数:
0
引用数:
0
h-index:
0
机构:
GLAXO RES LTD,GREENFORD UB6 OHE,MIDDLESEX,ENGLAND
GLAXO RES LTD,GREENFORD UB6 OHE,MIDDLESEX,ENGLAND
MUGGLETON, PW
[J].
JOURNAL OF ANTIBIOTICS,
1976,
29
(01)
: 29
-
37
[14]
REFINED CRYSTAL-STRUCTURE OF BETA-LACTAMASE FROM CITROBACTER-FREUNDII INDICATES A MECHANISM FOR BETA-LACTAM HYDROLYSIS
OEFNER, C
论文数:
0
引用数:
0
h-index:
0
机构:
F HOFFMANN LA ROCHE & CO LTD, CENT RES UNIT, CH-4002 BASEL, SWITZERLAND
OEFNER, C
DARCY, A
论文数:
0
引用数:
0
h-index:
0
机构:
F HOFFMANN LA ROCHE & CO LTD, CENT RES UNIT, CH-4002 BASEL, SWITZERLAND
DARCY, A
DALY, JJ
论文数:
0
引用数:
0
h-index:
0
机构:
F HOFFMANN LA ROCHE & CO LTD, CENT RES UNIT, CH-4002 BASEL, SWITZERLAND
DALY, JJ
GUBERNATOR, K
论文数:
0
引用数:
0
h-index:
0
机构:
F HOFFMANN LA ROCHE & CO LTD, CENT RES UNIT, CH-4002 BASEL, SWITZERLAND
GUBERNATOR, K
CHARNAS, RL
论文数:
0
引用数:
0
h-index:
0
机构:
F HOFFMANN LA ROCHE & CO LTD, CENT RES UNIT, CH-4002 BASEL, SWITZERLAND
CHARNAS, RL
HEINZE, I
论文数:
0
引用数:
0
h-index:
0
机构:
F HOFFMANN LA ROCHE & CO LTD, CENT RES UNIT, CH-4002 BASEL, SWITZERLAND
HEINZE, I
HUBSCHWERLEN, C
论文数:
0
引用数:
0
h-index:
0
机构:
F HOFFMANN LA ROCHE & CO LTD, CENT RES UNIT, CH-4002 BASEL, SWITZERLAND
HUBSCHWERLEN, C
WINKLER, FK
论文数:
0
引用数:
0
h-index:
0
机构:
F HOFFMANN LA ROCHE & CO LTD, CENT RES UNIT, CH-4002 BASEL, SWITZERLAND
WINKLER, FK
[J].
NATURE,
1990,
343
(6255)
: 284
-
288
[15]
COMPARATIVE-STUDY OF 7 CEPHALOSPORINS - SUSCEPTIBILITY TO BETA-LACTAMASES AND ABILITY TO PENETRATE SURFACE-LAYERS OF ESCHERICHIA-COLI
RICHMOND, MH
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BRISTOL,DEPT BACTERIOL,BRISTOL BS8 1TD,GLOUCESTERSHIRE,ENGLAND
UNIV BRISTOL,DEPT BACTERIOL,BRISTOL BS8 1TD,GLOUCESTERSHIRE,ENGLAND
RICHMOND, MH
WOTTON, S
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BRISTOL,DEPT BACTERIOL,BRISTOL BS8 1TD,GLOUCESTERSHIRE,ENGLAND
UNIV BRISTOL,DEPT BACTERIOL,BRISTOL BS8 1TD,GLOUCESTERSHIRE,ENGLAND
WOTTON, S
[J].
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,
1976,
10
(02)
: 219
-
222
[16]
DNA SEQUENCING WITH CHAIN-TERMINATING INHIBITORS
SANGER, F
论文数:
0
引用数:
0
h-index:
0
SANGER, F
NICKLEN, S
论文数:
0
引用数:
0
h-index:
0
NICKLEN, S
COULSON, AR
论文数:
0
引用数:
0
h-index:
0
COULSON, AR
[J].
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1977,
74
(12)
: 5463
-
5467
[17]
SAWAI T, 1988, REV INFECT DIS, V10, P721
[18]
A SET OF BACTERIAL STRAINS FOR EVALUATION OF BETA-LACTAMASE-STABILITY OF BETA-LACTAM ANTIBIOTICS
SAWAI, T
论文数:
0
引用数:
0
h-index:
0
SAWAI, T
YOSHIDA, T
论文数:
0
引用数:
0
h-index:
0
YOSHIDA, T
TSUKAMOTO, K
论文数:
0
引用数:
0
h-index:
0
TSUKAMOTO, K
YAMAGISHI, S
论文数:
0
引用数:
0
h-index:
0
YAMAGISHI, S
[J].
JOURNAL OF ANTIBIOTICS,
1981,
34
(10)
: 1318
-
1326
[19]
SAWAI T, 1982, J BACTERIOL, V152, P567
[20]
SIROT J, 1988, REV INFECT DIS, V10, P850
←
1
2
3
→