CHARACTERIZATION OF THE AIRWAY SMOOTH-MUSCLE MUSCARINIC RECEPTOR INVIVO

被引：11

作者：

HOWELL, RE ^{[1
]}

LAEMONT, K ^{[1
]}

GAUDETTE, R ^{[1
]}

RAYNOR, M ^{[1
]}

WARNER, A ^{[1
]}

NORONHABLOB, L ^{[1
]}

机构：

[1] NOVA PHARMACEUT CORP,BALTIMORE,MD 21224

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 197卷 / 01期

关键词：

MUSCARINIC RECEPTORS; BRONCHODILATOR AGENTS; IPRATROPIUM BROMIDE; CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD); NEUROGENIC BLADDER;

D O I：

10.1016/0014-2999(91)90372-W

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We examined the bronchodilator activity of eight subtype-selective and non-selective muscarinic antagonists in anesthetized, ventilated guinea pigs bronchoconstricted by carbachol aerosols. Relative bronchodilator potencies were consistent with M3 receptor antagonism and correlated with inhibition of bladder smooth muscle contraction in vivo. We conclude that the airway smooth muscle muscarinic receptor can be functionally characterized in vivo as M3 and that it is of the same subtype as the muscarinic receptor in bladder smooth muscle.

引用

页码：109 / 112

页数：4

共 10 条

[1]

DOODS HN, 1987, J PHARMACOL EXP THER, V242, P257

[2]

EGLEN RM, 1986, J AUTON PHARMACOL, V5, P323

[3] IDENTIFICATION OF 3 MUSCARINIC RECEPTOR SUBTYPES IN RAT LUNG USING BINDING-STUDIES WITH SELECTIVE ANTAGONISTS [J].