ASSAY OF FLUCONAZOLE BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH A MIXED-PHASE COLUMN

被引：36

作者：

WALLACE, JE

HARRIS, SC

GALLEGOS, J

FOULDS, G

CHEN, TJH

RINALDI, MG

机构：

[1] AUDIE L MURPHY MEM VET ADM MED CTR,LAB SERV,SAN ANTONIO,TX 78284

[2] PRECIS ANALYT LABS INC,SAN ANTONIO,TX 78216

[3] PFIZER INC,CENT RES,DEPT DRUG METAB,GROTON,CT 06340

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1992年 / 36卷 / 03期

关键词：

D O I：

10.1128/AAC.36.3.603

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A mixed-phase liquid chromatographic column was used to assay fluconazole in plasma, serum, and cerebrospinal fluid. The assay was linear from 0.2 to 20-mu-g/ml, with an average coefficient of variation of less than 5%. The partitioning of the drug between serum and cerebrospinal fluid was determined for 34 patients. The method was demonstrated to be suitable for both pharmacokinetic studies and monitoring of patients receiving treatment with this antifungal agent.

引用

页码：603 / 606

页数：4

共 8 条

[1]

ARNDT CAS, 1988, J INFECT DIS, V137, P178

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