THE INDUCTION OF TOLERANCE TO ALLOANTIGENS USING MHC CLASS-I MOLECULES

被引：19

作者：

WOOD, KJ ^{[1
]}

机构：

[1] UNIV OXFORD, JOHN RADCLIFFE HOSP, OXFORD, ENGLAND

来源：

CURRENT OPINION IN IMMUNOLOGY | 1993年 / 5卷 / 05期

关键词：

D O I：

10.1016/0952-7915(93)90134-E

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The identification of approaches that allow the adult immune system to be manipulated to facilitate the induction of tolerance to alloantigens is important for the development of more specific immunosuppressive therapy for use in transplantation. Novel strategies using genetic manipulation of recipient cells for the induction of tolerance to MHC class I antigens have been tested in experimental systems in the past year. These, together with new insights into the mechanisms responsible for maintaining peripheral tolerance, have advanced our progress in this challenging area of transplantation biology.

引用

收藏

页码：759 / 762

页数：4

相关论文

共 17 条

[1] MULTIPLE LEVELS OF PERIPHERAL TOLERANCE [J].

ARNOLD, B ;

SCHONRICH, G ;

HAMMERLING, GJ .

IMMUNOLOGY TODAY, 1993, 14 (01) :12-14

[2] INFLUENCE OF ANTIGEN DENSITY ON DEGREE OF CLONAL DELETION IN T-CELL RECEPTOR TRANSGENIC MICE [J].

AUPHAN, N ;

SCHONRICH, G ;

MALISSEN, M ;

BARAD, M ;

HAMMERLING, G ;

ARNOLD, B ;

MALISSEN, B ;

SCHMITTVERHULST, AM .

INTERNATIONAL IMMUNOLOGY, 1992, 4 (04) :541-547

[3]

BELL Y, 1993, TRANSPLANT P, V25, P359

[4] PEPTIDE-INDUCED CONFORMATIONAL-CHANGES IN CLASS-I HEAVY-CHAINS ALTER MAJOR HISTOCOMPATIBILITY COMPLEX RECOGNITION [J].

BLUESTONE, JA ;

JAMESON, S ;

MILLER, S ;

DICK, R .

JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 176 (06) :1757-1761

[5] ORGAN INJURY ASSOCIATED WITH EXTRATHYMIC INDUCTION OF IMMUNE TOLERANCE IN DOUBLY TRANSGENIC MICE [J].

FIELDS, LE ;

LOH, DY .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (13) :5730-5734

[6] TRANSPLANTATION EFFECTS OF A UNIQUE MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I MUTATION [J].

HASENKRUG, KJ ;

STIMPFLING, JH ;

WINN, HJ ;

NATHENSON, SG .

TRANSPLANTATION, 1992, 54 (02) :368-371

[7] AUTOIMMUNE DIABETES AS A CONSEQUENCE OF LOCALLY PRODUCED INTERLEUKIN-2 [J].

HEATH, WR ;

ALLISON, J ;

HOFFMANN, MW ;

SCHONRICH, G ;

HAMMERLING, G ;

ARNOLD, B ;

MILLER, JFAP .

NATURE, 1992, 359 (6395) :547-549

[8] CELL-CELL INTERACTION IN GRAFT-REJECTION RESPONSES - INDUCTION OF ANTI-ALLO-CLASS-I H-2 TOLERANCE IS PREVENTED BY IMMUNE-RESPONSES AGAINST ALLO-CLASS-II H-2-ANTIGENS COEXPRESSED ON TOLEROGEN [J].

HORI, S ;

KITAGAWA, S ;

IWATA, H ;

OCHIAI, T ;

ISONO, K ;

HAMAOKA, T ;

FUJIWARA, H .

JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 175 (01) :99-109

[9] EXPRESSION OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I ANTIGENS AT LOW-LEVELS IN THE THYMUS INDUCES T-CELL TOLERANCE VIA A NONDELETIONAL MECHANISM [J].

HUSBANDS, SD ;

SCHONRICH, G ;

ARNOLD, B ;

CHANDLER, PR ;

SIMPSON, E ;

PHILPOTT, KL ;

TOMLINSON, P ;

OREILLY, L ;

COOKE, A ;

MELLOR, AL .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1992, 22 (10) :2655-2661

[10] IMMUNOLOGICAL-UNRESPONSIVENESS INDUCED BY RECIPIENT CELLS TRANSFECTED WITH DONOR MHC GENES [J].

MADSEN, JC ;

SUPERINA, RA ;

WOOD, KJ ;

MORRIS, PJ .

NATURE, 1988, 332 (6160) :161-164