CASTRATION-INDUCED LYMPHOCYTOSIS IN PROSTATE-CANCER - POSSIBLE EVIDENCE FOR GONAD THYMUS ENDOCRINE INTERACTION IN MAN

被引：11

作者：

OLIVER, RTD

JOSEPH, JV

GALLAGHER, CJ

机构：

[1] Medical College, Royal London Hospital

来源：

UROLOGIA INTERNATIONALIS | 1995年 / 54卷 / 04期

关键词：

PROSTATE CANCER; GONAD THYMUS; INTERACTION;

D O I：

10.1159/000282729

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Prompted by evidence from animal studies that castration produces lymphocytosis associated with thymic hyperplasia, this paper has reviewed serial lymphocyte levels in patients with prostate cancer undergoing hormone treatment. On day 7, 5 of 12 patients (58%) showed diminished circulating lymphocyte levels (compared to day 0) reflecting the surge of testosterone after treatment with LHRH analogues, while on day 28 a reversal had occurred and 13 of 17 (77%) had increased lymphocytes (compared to day 0). Possible relevance of these observations to defining a subgroup of patients with hormone-sensitive cancer who might benefit from immunotherapy is discussed.

引用

页码：226 / 229

页数：4

共 15 条

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