THE MECHANISMS OF ACTION OF CYCLOSPORINE-A IN THE TREATMENT OF PSORIASIS

被引：110

作者：

WONG, RL ^{[1
]}

WINSLOW, CM ^{[1
]}

COOPER, KD ^{[1
]}

机构：

[1] UNIV MICHIGAN,MED CTR,DEPT DERMATOL,IMMUNODERMATOL UNIT,ANN ARBOR,MI 48109

来源：

IMMUNOLOGY TODAY | 1993年 / 14卷 / 02期

关键词：

D O I：

10.1016/0167-5699(93)90061-O

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This article describes the effects of cyclosporin A (CsA) on the immunopathological mechanisms operative in psoriasis, a human skin disease. The main focus is the effect of CsA on keratinocytes, T cells and antigen-presenting cells, the key players in lesional psoriatic skin. The effect of CsA on other cells, such as neutrophils and endothelial cells, which are important in the maintenance of psoriasis, are also discussed.

引用

页码：69 / 74

页数：6

共 75 条

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