THE MECHANISMS OF ACTION OF CYCLOSPORINE-A IN THE TREATMENT OF PSORIASIS

被引:110
作者
WONG, RL [1 ]
WINSLOW, CM [1 ]
COOPER, KD [1 ]
机构
[1] UNIV MICHIGAN,MED CTR,DEPT DERMATOL,IMMUNODERMATOL UNIT,ANN ARBOR,MI 48109
来源
IMMUNOLOGY TODAY | 1993年 / 14卷 / 02期
关键词
D O I
10.1016/0167-5699(93)90061-O
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
This article describes the effects of cyclosporin A (CsA) on the immunopathological mechanisms operative in psoriasis, a human skin disease. The main focus is the effect of CsA on keratinocytes, T cells and antigen-presenting cells, the key players in lesional psoriatic skin. The effect of CsA on other cells, such as neutrophils and endothelial cells, which are important in the maintenance of psoriasis, are also discussed.
引用
收藏
页码:69 / 74
页数:6
相关论文
共 75 条
[11]  
CHRISTOPHERS E, 1987, DERMATOLOGY GENERAL, P461
[12]  
COOPER KD, 1990, J IMMUNOL, V144, P4593
[13]   MECHANISMS OF CYCLOSPORINE-A INHIBITION OF ANTIGEN-PRESENTING ACTIVITY IN UNINVOLVED AND LESIONAL PSORIATIC EPIDERMIS [J].
COOPER, KD ;
BAADSGAARD, O ;
ELLIS, CN ;
DUELL, E ;
VOORHEES, JJ .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1990, 94 (05) :649-656
[14]   LANGERHANS CELL SENSITIVITY TO INVITRO VERSUS INVIVO LOADING WITH CYCLOSPORINE-A [J].
COOPER, KD ;
BAADSGAARD, O ;
DUELL, E ;
FISHER, G ;
ELLIS, CN ;
VOORHEES, JJ .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1992, 98 (02) :259-260
[15]   LYMPHOCYTE-T-ACTIVATING PROPERTIES OF EPIDERMAL ANTIGEN-PRESENTING CELLS FROM NORMAL AND PSORIATIC SKIN - EVIDENCE THAT PSORIATIC EPIDERMAL ANTIGEN-PRESENTING CELLS RESEMBLE CULTURED NORMAL LANGERHANS CELLS [J].
DEMIDEM, A ;
TAYLOR, JR ;
GRAMMER, SF ;
STREILEIN, JW .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1991, 97 (03) :454-460
[16]  
DUNCAN JI, 1991, CLIN EXP IMMUNOL, V85, P293
[17]   CYCLOSPORINE-A INHIBITS THE ANTIGEN-PRESENTING FUNCTIONS OF FRESHLY ISOLATED HUMAN LANGERHANS CELLS-INVITRO [J].
DUPUY, P ;
BAGOT, M ;
MICHEL, L ;
DESCOURT, B ;
DUBERTRET, L .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1991, 96 (04) :408-413
[18]  
ELDER JT, 1991, J INVEST DERMATOL, V96, pA612
[19]   CYCLOSPORINE FOR PLAQUE-TYPE PSORIASIS - RESULTS OF A MULTIDOSE, DOUBLE-BLIND TRIAL [J].
ELLIS, CN ;
FRADIN, MS ;
MESSANA, JM ;
BROWN, MD ;
SIEGEL, MT ;
HARTLEY, AH ;
ROCHER, LL ;
WHEELER, S ;
HAMILTON, TA ;
PARISH, TG ;
ELLISMADU, M ;
DUELL, E ;
ANNESLEY, TM ;
COOPER, KD ;
VOORHEES, JJ .
NEW ENGLAND JOURNAL OF MEDICINE, 1991, 324 (05) :277-284
[20]   PSORIASIS INDUCED AT THE INJECTION SITE OF RECOMBINANT INTERFERON-GAMMA - RESULTS OF IMMUNOHISTOLOGIC INVESTIGATIONS [J].
FIERLBECK, G ;
RASSNER, G ;
MULLER, C .
ARCHIVES OF DERMATOLOGY, 1990, 126 (03) :351-355