INHIBITION OF SV40 GENE-EXPRESSION BY MICROINJECTED SMALL ANTISENSE RNA AND DNA-MOLECULES

被引：21

作者：

GRAESSMANN, M

MICHAELS, G

BERG, B

GRAESSMANN, A

机构：

[1] FREE UNIV BERLIN,INST MOLEK BIOL & BIOCHEM,ARNIMALLEE 22,BERLIN 33,GERMANY

[2] NIH,BETHESDA,MD 20892

来源：

NUCLEIC ACIDS RESEARCH | 1991年 / 19卷 / 01期

关键词：

D O I：

10.1093/nar/19.1.53

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We tested the impact of antisense RNA and DNA molecules on SV40 gene expression by microinjection into TC7 cells. Short antisense stretches, complementary to either hairpin or loop structures on the T antigen mRNA, inhibited T antigen synthesis. In contrast, full-length antisense RNA and DNA molecules did not effect T antigen synthesis.

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页码：53 / 59

页数：7

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