IDENTIFICATION OF A NOVEL MEMBER OF THE PENTRAXIN FAMILY IN XENOPUS-LAEVIS

被引:56
作者
SEERY, LT
SCHOENBERG, DR
BARBAUX, S
SHARP, PM
WHITEHEAD, AS
机构
[1] UNIV DUBLIN TRINITY COLL, DEPT GENET, DUBLIN 2, IRELAND
[2] UNIV DUBLIN TRINITY COLL, INST BIOTECHNOL, DUBLIN 2, IRELAND
[3] UNIFORMED SERV UNIV HLTH SCI, DEPT PHARMACOL, BETHESDA, MD 20814 USA
关键词
D O I
10.1098/rspb.1993.0112
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Pentraxins are a family of acute phase reactants. Two family members, C-reactive protein (CRP) and serum amyloid P component (SAP), are known in a range of mammalian species. CRP and SAP are both about 200 residues long, and arose from a gene duplication event, apparently before the divergence of the mammalian orders. To elucidate the origins of mammalian pentraxins, we have searched for pentraxin-coding genes in the amphibian Xenopus laevis. We have identified a gene determining a protein (XL-PXN1) which is about twice the size expected: the XL-PXN1 gene appears to be a fusion between regions encoding an amino-terminal peptide of unknown function and a carboxy-terminal pentraxin. The pentraxin domain is more divergent from CRP and SAP than they are from each other: it provides an outgroup for analysis of the evolution of mammalian pentraxins and confirms that putative CRP and SAP proteins partly characterized in non-vertebrate species cannot be true homologues of the mammalian proteins.
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页码:263 / 270
页数:8
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