PROGRESS OF MYELINATION IN THE HUMAN FETAL SPINAL NERVE ROOTS, SPINAL-CORD AND BRAIN-STEM WITH MYELIN BASIC-PROTEIN IMMUNOHISTOCHEMISTRY

被引：39

作者：

TANAKA, S ^{[1
]}

MITO, T ^{[1
]}

TAKASHIMA, S ^{[1
]}

机构：

[1] NATL CTR HOSP MENTAL NERVOUS & MUSCULAR DISORDERS,NATL CTR NEUROL & PSYCHIAT,DIV CHILD NEUROL,KODAIRA,TOKYO 187,JAPAN

来源：

EARLY HUMAN DEVELOPMENT | 1995年 / 41卷 / 01期

关键词：

MYELINATION; HUMAN BRAIN DEVELOPMENT; MYELIN BASIC PROTEIN; LUXOL-FAST-BLUE STAINING; SPINAL NERVE ROOTS;

D O I：

10.1016/0378-3782(94)01608-R

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The early progress of myelination was studied, by means of myelin basic protein (MBP) immunohistochemistry and luxol-fast-blue (LFB) staining, in the spinal cord, spinal nerve roots and brainstem of 66 fetuses and neonates. The degree of myelination was classified from 1 (slight) to 4 (mature). MBP immunoreactivity exhibited slight LFB positivity. Myelination first occurred in the medial longitudinal fasciculus at 20 weeks of age, reaching degree 4 at 34 weeks, but began at 23-24 weeks in the other sites. Myelination of spinal nerve roots progressed with gestation and attained degree 4 at 35-36 weeks. The cuneate fasciculus also reached degree 4 at 34-36 weeks, but corticospinal tracts and solitary tracts, which exhibited long myelinating phases, were slow and incomplete at 40 weeks. This normal development of MBP and LFB myelination can be used for the assessment of delayed myelination in fetal and neonatal diseases.

引用

页码：49 / 59

页数：11

共 27 条

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