CALCIUM REGULATING HORMONES IN ESSENTIAL-HYPERTENSION - IMPORTANCE OF GENDER

被引：50

作者：

YOUNG, EW

MCCARRON, DA

MORRIS, CD

机构：

[1] The Division of Nephrology and Hypertension, Oregon Health Sciences University

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1990年 / 3卷 / 08期

关键词：

Blood pressure; Calcitriol; Hypertension; Parathyroid hormone; Vitamin D;

D O I：

10.1093/ajh/3.8.161

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Alterations of calcium metabolism have been described in human essential hypertension and experimental hypertension. We investigated the interrelationship of parathyroid hormone (PTH) and l, 25(OH)2-vitamin D (l, 25(OH)2D) in patients with untreated essential hypertension as compared to normotensive controls. The hypertensive subjects (n = 75; 43 men, 32 women) had a mean blood pressure of 138 ± 8/95 ± 5 mm Hg as compared with 120 ± 11/80 ± 8 in the normotensive group (n = 40; 22 men, 18 women). Serum PTH was measured with an intact molecule immunochemiluminometric assay and l, 25(OH)2D was measured with radioimmunoassay after HPLC separation. Hypertensive men had PTH levels that were 36% higher than normotensive men (5.3 ± 2.9 v 3.9 ± 0.8 pmol/L, P =. 005). When blood pressure was analyzed as a continuous variable, there was a direct correlation between it and serum PTH in men (r =. 31, P =. 004). In women, by contrast, there was no difference in serum PTH between hypertensive and normotensive subjects and no relationship between blood pressure and the serum PTH concentration. Blood pressure was inversely correlated with serum phosphorus levels in both sexes (r = −0.20, P =. 04). In men, the elevated serum PTH levels and depressed serum phosphorus levels would have predicted that serum l, 25(OH)2D would be higher in the hypertensive subjects. However, that was not observed, as serum l, 25(OH)2D was slightly lower in hypertensive (38.3 ± 15.2 pg/mL) than normotensive men (42.7 ± 11.3, P =. 21). In women, l, 25(OH)2D levels were similar in hypertension (38.8 ± 15.1) and normotension (42.1 ± 15.1, P =. 36), although serum phosphorus tended to be lower in the hypertensive subjects. Thus, we have identified overtly elevated PTH levels in hypertensive men and l, 25(OH)2D concentrations that are inappropriately low for the prevailing serum PTH and phosphorus concentrations, a biochemical pattern of calcium metabolism not observed in women with elevated arterial pressures. © 1990 by the American Journal of Hypertension, Ltd.

引用

页码：S161 / S166

页数：6

共 38 条

[11]

Nichols G.A., Cline W.H.J., Parathyroid hormone-induced changes in cyclic nucleotide levels during relaxation of the rat aorta, Life Sci, 40, pp. 2351-2359, (1987)

[12]

Gairard A., Berthelot A., Schleiffer R., Pernot F., Parathyroidectomy significantly decreases hypertension in spontaneously hypertensive and deoxycortisone plus saline treated rats, Can J Physiol Pharmacol, 60, pp. 208-212, (1982)

[13]

Mann J.F.E., Wiecek A., Bommer J., Et al., Effects of parathyroidectomy on blood pressure in spontaneously hypertensive rats, Nephron, 45, pp. 46-52, (1987)

[14]

Rosenthal F.D., Roy S., Hypertension and hyperparathyroidism, Br Med J, 4, pp. 396-397, (1972)

[15]

Hellstrom J., Birke G., Edvall C.A., Hypertension in hyperparathyroidism, Br J Urol, 30, pp. 13-24, (1958)

[16]

Walters M.R., Wicker D.C., Riggle P.C., 1, 25-Dihydroxyvitamin D3 receptors identified in the rat heart, J Mol Cell Cardiol, 18, pp. 67-72, (1986)

[17]

Kawashima H., Receptor for 1, 25-dihydroxyvitamin D in a vascular smooth muscle cell line derived from rat aorta, Biochem Biophys Res Commun, 146, pp. 1-6, (1987)

[18]

Merke J., Hof man W., Goldschmidt G., Ritz E., Demonstration of l, 25(OH)2 vitamin D3 receptors and actions in vascular smooth muscle in vitro, Calcif Tissue Int, 41, pp. 112-114, (1987)

[19]

Merke J., Habenicht A., Goldschmidt D., Ritz E., Evidence for l, 25(OH)2D3 receptors in bovine aortic endothelial cells (abst), J Bone Miner Res, 1, (1986)

[20]

Bukoski R.D., Xue H., McCarron D.A., Effect of l, 25(OH)2 vitamin D3 and ionized Ca2 + on 4 5Ca uptake by primary cultures of aortic myocytes of spontaneously hypertensive and Wistar-Kyoto normotensive rats, Biochem Biophys Res Commun, 146, pp. 1330-1335, (1987)

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