CHRONIC EFFECTS OF PHENYTOIN ON BRAIN-STEM AUDITORY EVOKED-POTENTIALS IN MAN

被引:18
作者
CHAN, YW [1 ]
WOO, E [1 ]
YU, YL [1 ]
机构
[1] UNIV HONG KONG,QUEEN MARY HOSP,DEPT MED,HONG KONG,HONG KONG
来源
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY | 1990年 / 77卷 / 02期
关键词
Brain-stem auditory evoked potential (BAEP); Chronic effects; Phenytoin;
D O I
10.1016/0168-5597(90)90025-9
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
The effects of phenytoin (PHT) on brain-stem auditory evoked potentials (BAEPs) were studied in 65 epileptic patients who received long-term PHT monotherapy at therapeutic and supra-therapeutic levels with no clinical evidence of brain-stem toxicity. Abnormal BAEPs were found in 7.5% and 33.3% of patients with therapeutic and supra-therapeutic PHT levels respectively. Serum PHT levels had a trend towards a positive relationship with the I-V interpeak latency (IPL), and a significant negative relationship with the amplitudes of waves I and V. at supra-therapeutic levels, both I-V and I-III IPLs were significantly prolonged while at therapeutic evels onl I-III IPLs were prolonged. The absolute latency of wave I was prolonged in both the therapeutic and the supra-therapeutic groups. These results suggest that PHT acts both peripherally on either the auditory nerve or the cochlea, and centrally on brain-stem conduction. © 1990.
引用
收藏
页码:119 / 126
页数:8
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