CHRONIC EFFECTS OF PHENYTOIN ON BRAIN-STEM AUDITORY EVOKED-POTENTIALS IN MAN

被引：18

作者：

CHAN, YW ^{[1
]}

WOO, E ^{[1
]}

YU, YL ^{[1
]}

机构：

[1] UNIV HONG KONG,QUEEN MARY HOSP,DEPT MED,HONG KONG,HONG KONG

来源：

ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY | 1990年 / 77卷 / 02期

关键词：

Brain-stem auditory evoked potential (BAEP); Chronic effects; Phenytoin;

D O I：

10.1016/0168-5597(90)90025-9

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The effects of phenytoin (PHT) on brain-stem auditory evoked potentials (BAEPs) were studied in 65 epileptic patients who received long-term PHT monotherapy at therapeutic and supra-therapeutic levels with no clinical evidence of brain-stem toxicity. Abnormal BAEPs were found in 7.5% and 33.3% of patients with therapeutic and supra-therapeutic PHT levels respectively. Serum PHT levels had a trend towards a positive relationship with the I-V interpeak latency (IPL), and a significant negative relationship with the amplitudes of waves I and V. at supra-therapeutic levels, both I-V and I-III IPLs were significantly prolonged while at therapeutic evels onl I-III IPLs were prolonged. The absolute latency of wave I was prolonged in both the therapeutic and the supra-therapeutic groups. These results suggest that PHT acts both peripherally on either the auditory nerve or the cochlea, and centrally on brain-stem conduction. © 1990.

引用

页码：119 / 126

页数：8

共 21 条

[11]

LENARZ T, 1987, Clinical Neurology and Neurosurgery, V89, P101

[12] EFFECTS OF PHENYTOIN ADMINISTRATION ON VESTIBULAR FUNCTION IN THE RAT [J].

MAMELI, O ;

TOLU, E ;

CARIA, MA ;

MELIS, F ;

SECHI, GP .

EPILEPSIA, 1985, 26 (03) :262-267

[13] FURTHER OBSERVATIONS ON THE ACTION OF PHENYTOIN ON THE CEREBELLUM IN RATS - INVOLVEMENT OF THE LATERAL RETICULAR NUCLEUS [J].

MAMELI, O ;

TOLU, E .

EPILEPSIA, 1984, 25 (03) :363-367

[14] CORRELATIONS BETWEEN CEREBELLAR ACTIVITY AND CHRONIC NONTOXIC ADMINISTRATION OF PHENYTOIN IN RATS [J].

MAMELI, O ;

TOLU, E ;

MELIS, F ;

CARIA, MA ;

PALMIERI, G ;

PIREDDA, S .

EPILEPSIA, 1984, 25 (01) :33-39

[15] CONTRIBUTIONS FROM THE AUDITORY-NERVE TO THE BRAIN-STEM AUDITORY EVOKED-POTENTIALS (BAEPS) - RESULTS OF INTRACRANIAL RECORDING IN MAN [J].

MOLLER, AR ;

JANNETTA, PJ ;

SEKHAR, LN .

ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1988, 71 (03) :198-211

[16]

RODIN E, 1982, ELECTROEN CLIN NEURO, V53, pP25

[17]

RODIN E, 1980, ELECTROEN CLIN NEURO, V49, pP26

[18] AUDITORY BRAIN-STEM RESPONSES IN NEUROLOGICAL DISEASE [J].

STARR, A ;

ACHOR, LJ .

ARCHIVES OF NEUROLOGY, 1975, 32 (11) :761-768

[19]

STOCKARD JJ, 1977, ELECTROEN CLIN NEURO, V43, P550

[20]

Trimble M R, 1976, Psychol Med, V6, P169

← 1 2 3 →