ASYMMETRIC-SYNTHESIS .34. SYNTHESIS OF SPIRO-PIPERIDINE DERIVATIVES VIA THE CN(R,S) METHOD

被引：13

作者：

RIBEIRO, CMR ^{[1
]}

DEMELO, SJ ^{[1
]}

BONIN, M ^{[1
]}

QUIRION, JC ^{[1
]}

HUSSON, HP ^{[1
]}

机构：

[1] UNIV PARIS 05,FAC SCI PHARMACEUT & BIOL,CNRS,CHIM THERAPEUT LAB,F-75270 PARIS 06,FRANCE

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 39期

关键词：

ASYMMETRIC SYNTHESIS; SPIRO-PIPERIDINE; 5-AZASPIRO-[3,5] NONANE; 6-AZASPIRO-[4,5] DECANE;

D O I：

10.1016/0040-4039(94)85367-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

5-Aza-spiro-[3,5] nonane and 6-aza-spiro-[4,5] decane derivatives 5 and 9 have been prepared from 2-cyano-6-pheoyloxazolopiperidine synthon 2b via alkylation followed by cyclisation of the resulting halogeno aminonitrile under dissolving metal conditions.

引用

页码：7227 / 7230

页数：4

共 24 条

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