DIFFERENTIAL EFFECTS OF ANTIOXIDANTS, STEROIDS AND OTHER COMPOUNDS ON BENZO(A)PYRENE 3-HYDROXYLASE ACTIVITY IN VARIOUS TISSUES OF RAT

被引：37

作者：

RAHIMTULA, AD ^{[1
]}

ZACHARIAH, PK ^{[1
]}

OBRIEN, PJ ^{[1
]}

机构：

[1] MEM UNIV NEWFOUNDLAND,FAC MED,ST JOHNS A1B 3X4,NEWFOUNDLAND,CANADA

来源：

BRITISH JOURNAL OF CANCER | 1979年 / 40卷 / 01期

关键词：

D O I：

10.1038/bjc.1979.146

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Antioxidants were found to inhibit the mixed-function oxidation of benzo(a)pyrene in several tissues of untreated and 3-methylcholanthrene-pretreated rats. The enzyme systems in the liver, kidney and stomach were much more susceptible to inhibition than those in the lung, adrenal, colon and small intestine. In all tissues except the stomach it was found that 3-methylcholanthrene pretreatment led to a decrease in inhibition of benzo(a)pyrene 3-hydroxylase activity. It is suggested that antioxidants exert their protective effect against cancer by inhibiting the formation of carcinogenic metabolites. Of the various steroids tested, only 17β-oestradiol and oestrone were significantly inhibitory in most tissues. Cholesterol was found to increase benzo(a)pyrene 3-hydroxylase activity in the gastrointestinal tract. © 1979, Nature Publishing Group. All Rights Reserved.

引用

页码：105 / 112

页数：8

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