CURRENT PERSPECTIVES IN THE VIROLOGY AND MOLECULAR-BIOLOGY OF HEPATITIS-A VIRUS

被引：38

作者：

LEMON, SM ^{[1
]}

ROBERTSON, BH ^{[1
]}

机构：

[1] CTR DIS CONTROL,CTR INFECT DIS,DIV VIRAL & RICKETTSIAL DIS,HEPATITIS BRANCH,ATLANTA,GA 30333

来源：

SEMINARS IN VIROLOGY | 1993年 / 4卷 / 05期

关键词：

PICORNAVIRIDAE; TRANSLATION INITIATION; POLYPROTEIN PROCESSING; ANTIGENIC STRUCTURE; GENOTYPES;

D O I：

10.1006/smvy.1993.1025

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Several unique features of hepatitis A virus (HAV) support its classification within a new genus, hepatovirus, of the family Picornaviridae. The structure of the HAV capsid may differ from other picornaviruses as indirect evidence suggests the absence of a myristylated VP4 protein. The replication of HAV is unusually slow in cell culture and typically results in persistent infection. Other evidence suggests fundamental differences between HAV and other picornaviruses with respect to viral translation, polyprotein processing and RNA replication. © 1993 Academic Press. All rights reserved.

引用

页码：285 / 295

页数：11

共 61 条

[1] CYTOPATHOLOGY, PLAQUE-ASSAY, AND HEAT INACTIVATION OF HEPATITIS-A VIRUS-STRAIN HM175 [J].

ANDERSON, DA .

JOURNAL OF MEDICAL VIROLOGY, 1987, 22 (01) :35-44

[2] MORPHOGENESIS OF HEPATITIS-A VIRUS - ISOLATION AND CHARACTERIZATION OF SUBVIRAL PARTICLES [J].

ANDERSON, DA ;

ROSS, BC .

JOURNAL OF VIROLOGY, 1990, 64 (11) :5284-5289

[3] RESTRICTED REPLICATION OF HEPATITIS-A VIRUS IN CELL-CULTURE - ENCAPSIDATION OF VIRAL-RNA DEPLETES THE POOL OF RNA AVAILABLE FOR REPLICATION [J].

ANDERSON, DA ;

ROSS, BC ;

LOCARNINI, SA .

JOURNAL OF VIROLOGY, 1988, 62 (11) :4201-4206

[4] PRIMARY ISOLATION AND SERIAL PASSAGE OF HEPATITIS-A VIRUS-STRAINS IN PRIMATE CELL-CULTURES [J].

BINN, LN ;

LEMON, SM ;

MARCHWICKI, RH ;

REDFIELD, RR ;

GATES, NL ;

BANCROFT, WH .

JOURNAL OF CLINICAL MICROBIOLOGY, 1984, 20 (01) :28-33

[5] THE 5' NONTRANSLATED REGION OF HEPATITIS-A VIRUS-RNA - SECONDARY STRUCTURE AND ELEMENTS REQUIRED FOR TRANSLATION INVITRO [J].

BROWN, EA ;

DAY, SP ;

JANSEN, RW ;

LEMON, SM .

JOURNAL OF VIROLOGY, 1991, 65 (11) :5828-5838

[6] CHARACTERIZATION OF A SIMIAN HEPATITIS-A VIRUS (HAV) - ANTIGENIC AND GENETIC COMPARISON WITH HUMAN HAV [J].

BROWN, EA ;

JANSEN, RW ;

LEMON, SM .

JOURNAL OF VIROLOGY, 1989, 63 (11) :4932-4937

[7] RAPID COMPLETION OF THE REPLICATION CYCLE OF HEPATITIS-A VIRUS SUBSEQUENT TO REVERSAL OF GUANIDINE INHIBITION [J].

CHO, MW ;

EHRENFELD, E .

VIROLOGY, 1991, 180 (02) :770-780

[8] MYRISTYLATION OF PICORNAVIRUS CAPSID PROTEIN VP4 AND ITS STRUCTURAL SIGNIFICANCE [J].

CHOW, M ;

NEWMAN, JFE ;

FILMAN, D ;

HOGLE, JM ;

ROWLANDS, DJ ;

BROWN, F .

NATURE, 1987, 327 (6122) :482-486

[9] COMPLETE NUCLEOTIDE-SEQUENCE OF AN ATTENUATED HEPATITIS-A VIRUS - COMPARISON WITH WILD-TYPE VIRUS [J].

COHEN, JI ;

ROSENBLUM, B ;

TICEHURST, JR ;

DAEMER, RJ ;

FEINSTONE, SM ;

PURCELL, RH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (08) :2497-2501

[10] ATTENUATION AND CELL-CULTURE ADAPTATION OF HEPATITIS-A VIRUS (HAV) - A GENETIC-ANALYSIS WITH HAV CDNA [J].

COHEN, JI ;

ROSENBLUM, B ;

FEINSTONE, SM ;

TICEHURST, J ;

PURCELL, RH .

JOURNAL OF VIROLOGY, 1989, 63 (12) :5364-5370

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