CURRENT PERSPECTIVES IN THE VIROLOGY AND MOLECULAR-BIOLOGY OF HEPATITIS-A VIRUS

被引：38

作者：

LEMON, SM ^{[1
]}

ROBERTSON, BH ^{[1
]}

机构：

[1] CTR DIS CONTROL,CTR INFECT DIS,DIV VIRAL & RICKETTSIAL DIS,HEPATITIS BRANCH,ATLANTA,GA 30333

来源：

SEMINARS IN VIROLOGY | 1993年 / 4卷 / 05期

关键词：

PICORNAVIRIDAE; TRANSLATION INITIATION; POLYPROTEIN PROCESSING; ANTIGENIC STRUCTURE; GENOTYPES;

D O I：

10.1006/smvy.1993.1025

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Several unique features of hepatitis A virus (HAV) support its classification within a new genus, hepatovirus, of the family Picornaviridae. The structure of the HAV capsid may differ from other picornaviruses as indirect evidence suggests the absence of a myristylated VP4 protein. The replication of HAV is unusually slow in cell culture and typically results in persistent infection. Other evidence suggests fundamental differences between HAV and other picornaviruses with respect to viral translation, polyprotein processing and RNA replication. © 1993 Academic Press. All rights reserved.

引用

页码：285 / 295

页数：11

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