MUTATIONS AT THE MOUSE MICROPHTHALMIA LOCUS ARE ASSOCIATED WITH DEFECTS IN A GENE ENCODING A NOVEL BASIC-HELIX-LOOP-HELIX-ZIPPER PROTEIN

被引：962

作者：

HODGKINSON, CA ^{[1
]}

MOORE, KJ ^{[1
]}

NAKAYAMA, A ^{[1
]}

STEINGRIMSSON, E ^{[1
]}

COPELAND, NG ^{[1
]}

JENKINS, NA ^{[1
]}

ARNHEITER, H ^{[1
]}

机构：

[1] NCI,FREDERICK CANC RES & DEV CTR,BASIC RES PROGRAM,ADV BIOSCI LABS,MAMMALIAN GENET LAB,FREDERICK,MD 21702

来源：

CELL | 1993年 / 74卷 / 02期

关键词：

D O I：

10.1016/0092-8674(93)90429-T

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mice with mutations at the microphthalmia (mi) locus have some or all of the following defects: loss of pigmentation, reduced eye size, failure of secondary bone resorption, reduced numbers of mast cells, and early onset of deafness. Using a transgenic insertional mutation at this locus, we have identified a gene whose expression is disrupted in transgenic animals. This gene encodes a novel member of the basic-helix-loop-helix-leucine zipper (bHLH-ZIP) protein family of transcription factors, is altered in mice carrying two independent mi alleles (mi and mi(ws)), and is expressed in the developing eye, ear, and skin, all anatomical sites affected by mi. The multiple spontaneous and induced mutations available at mi provide a unique biological resource for studying the role of a bHLH-ZIP protein in mammalian development.

引用

页码：395 / 404

页数：10

共 63 条

[11] A HELIX-LOOP-HELIX PROTEIN RELATED TO THE IMMUNOGLOBULIN-E BOX-BINDING PROTEINS
CARR, CS
SHARP, PA
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (08) : 4384 - 4388
[12] OPTIMAL CONDITIONS FOR DIRECTLY SEQUENCING DOUBLE-STRANDED PCR PRODUCTS WITH SEQUENASE
CASANOVA, JL
PANNETIER, C
JAULIN, C
KOURILSKY, P
[J]. NUCLEIC ACIDS RESEARCH, 1990, 18 (13) : 4028 - 4028
[13] Chromczynski P, 1987, ANAL BIOCHEM, V162, P156
[14] THE MYC ONCOGENE - ITS ROLE IN TRANSFORMATION AND DIFFERENTIATION
COLE, MD
[J]. ANNUAL REVIEW OF GENETICS, 1986, 20 : 361 - 384
[15] DEVELOPMENT AND APPLICATIONS OF A MOLECULAR GENETIC-LINKAGE MAP OF THE MOUSE GENOME
COPELAND, NG
JENKINS, NA
[J]. TRENDS IN GENETICS, 1991, 7 (04) : 113 - 118
[16] THE C-FMS GENE COMPLEMENTS THE MITOGENIC DEFECT IN MAST-CELLS DERIVED FROM MUTANT W-MICE BUT NOT MI (MICROPHTHALMIA) MICE
DUBREUIL, P
FORRESTER, L
ROTTAPEL, R
REEDIJK, M
FUJITA, J
BERNSTEIN, A
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (06) : 2341 - 2345
[17] INDUCTION OF APOPTOSIS IN FIBROBLASTS BY C-MYC PROTEIN
EVAN, GI
WYLLIE, AH
GILBERT, CS
LITTLEWOOD, TD
LAND, H
BROOKS, M
WATERS, CM
PENN, LZ
HANCOCK, DC
[J]. CELL, 1992, 69 (01) : 119 - 128
[18] FARRER LA, 1992, J MED GENET, V27, P618
[19] RECOGNITION BY MAX OF ITS COGNATE DNA THROUGH A DIMERIC B/HLH/Z DOMAIN
FERREDAMARE, AR
PRENDERGAST, GC
ZIFF, EB
BURLEY, SK
[J]. NATURE, 1993, 363 (6424) : 38 - 45
[20] TFEB HAS DNA-BINDING AND OLIGOMERIZATION PROPERTIES OF A UNIQUE HELIX LOOP HELIX LEUCINE-ZIPPER FAMILY
FISHER, DE
CARR, CS
PARENT, LA
SHARP, PA
[J]. GENES & DEVELOPMENT, 1991, 5 (12A) : 2342 - 2352

← 1 2 3 4 5 6 7 →