NECROTIZING ENTEROCOLITIS AND HYPOTHYROIDISM IN A NEWBORN-INFANT - TREATMENT WITH INTRAVENOUS L-THYROXINE

被引：23

作者：

AMER, T ^{[1
]}

DAVID, R ^{[1
]}

OBERFIELD, SE ^{[1
]}

机构：

[1] NYU,MED CTR,DEPT PEDIAT ENDOCRINOL,NEW YORK,NY 10016

来源：

AMERICAN JOURNAL OF PERINATOLOGY | 1994年 / 11卷 / 01期

关键词：

D O I：

10.1055/s-2007-994530

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Gastrointestinal complications of hypothyroidism are well documented and include constipation, obstipation, and abdominal distention, as well as ileus, pseudo-obstruction, tumorlike mass of the intestine, and megacolon. We report herein on a 2-week-old, full-term female infant, who had both necrotizing enterocolitis (NEC) and congenital hypothyroidism. We further describe the response to therapy with intravenous L-thyroxine. To our knowledge, the patient's course is the first report of intravenous L-thyroxine in the management of congenital hypothyroidism when oral replacement is not an option. The possible causal relationship between NEC and hypothyroidism is discussed.

引用

页码：30 / 32

页数：3

共 17 条

[11]

Kowalewski K., Kolodej A., Myoelectrical and mechanical activity of stomach and intestine in hypothyroid dogs, Digest Dis, 22, pp. 235-240, (1977)

[12]

Christensen J., Scliedle I.I.P., Clifton J.A., The basic electrical rhythm of the duodenum in normal human subjects and in patients with thyroid disease, J Clin Invest, 43, pp. 1659-1667, (1964)

[13]

Kliegman R.M., Models of the pathogenesis of necrotizing enterocolitis, J Pediatr, 117, pp. S2-S5, (1990)

[14]

Yao A.C., Martinussen M., Johansen O.J., Burbakk A.M., Phototherapy associated changes in the mesenteric blood How (BF) response in neonates, Pediatr Res, 31, (1992)

[15]

Birk E., Tyndall M.R., Erickson C., Rudolph A.M., Robert J.M., Effects of thyroid hormone on myocardial adrenergic B-receptor responsiveness and function during late gestation, Pediatr Res, 31, pp. 468-476, (1992)

[16]

Vulsma T., Gons M.H., De Vijlder J.J.M., Maternal fetal transfer of thyroxine in congenital hypothyroidism due to a total organification defect or thyroid agenesis, N Engl J Med, 321, pp. 13-16, (1989)

[17]

Landenson P.W., Goldenheim P.D., Cooper D.S., Miller M.A., Ridgwav C.E., Early peripheral responses to intravenous L-thvroxine in primary hypothyroidism, A J Med, 73, pp. 467-474, (1982)

← 1 2 →