A SYNTHETIC APPROACH TO THE PSEUDOPTEROSINS USING CASCADE TECHNOLOGY

被引：26

作者：

HARROWVEN, DC ^{[1
]}

DENNISON, ST ^{[1
]}

HOWES, P ^{[1
]}

机构：

[1] GLAXO GRP RES LTD,GREENFORD UB6 0HE,MIDDX,ENGLAND

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 24期

关键词：

D O I：

10.1016/S0040-4039(00)73163-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A rapid synthetic entry towards the pseudopterosins, a class of diterpenes which display potent anti-inflammatory and analgesic properties, is described. The key feature of this approach is the use of a sequential intramolecular, Lewis acid mediated Friedel-Crafts alkylation - Friedel-Crafts acylation sequence, viz 14 to 15, to establish the tricyclic carbon framework.

引用

页码：4243 / 4246

页数：4

共 23 条

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[6] AN INSIGHT INTO THE T-BUTYLBROMIDE DIMETHYL-SULFOXIDE REAGENT - A NOVEL APPLICATION IN LIGNAN TOTAL SYNTHESIS
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[J]. TETRAHEDRON LETTERS, 1993, 34 (20) : 3323 - 3326
[7] A CONCISE SYNTHESIS OF TAIWANIN-E USING A MICHAEL INITIATED RING-CLOSURE PROTOCOL
HARROWVEN, DC
[J]. TETRAHEDRON LETTERS, 1991, 32 (30) : 3735 - 3738
[8] CASCADE RADICAL REACTIONS IN SYNTHESIS - CONDENSED THIOPHENES FROM KETENETHIOACETALS
HARROWVEN, DC
[J]. TETRAHEDRON LETTERS, 1993, 34 (35) : 5653 - 5656
[9] THE ADDITION OF ORGANOLITHIUMS TO KETENETHIOACETALS - A NEW CYCLOPENTANNULATION SEQUENCE LEADING TO INDANES
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[J]. TETRAHEDRON LETTERS, 1992, 33 (20) : 2879 - 2882
[10] NEW MARINE DITERPENOIDS, INCLUDING A UNIQUE HYDROPEROXIDE, FROM A CARIBBEAN GORGONIAN CORAL OF THE GENUS PSEUDOPTEROGORGIA
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BURCH, MT
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