ENANTIOMERICALLY PURE ISOXAZOLINES VIA ADDITION OF NITRILE OXIDES TO CHIRAL N-ACRYLOYL TOLUENE-2-ALPHA-SULTAMS

被引：86

作者：

OPPOLZER, W

KINGMA, AJ

PILLAI, SK

机构：

[1] Département de Chimie Organique, Université de Genève

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 37期

关键词：

D O I：

10.1016/S0040-4039(00)93489-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New saccharine-derived, crystalline acryloylsultams 12 undergo efficient 1,3-dipolar cycloadditions of nitrile oxides with greater-than-or-equal-to 95:5 stereoface discrimination. Products 13 or 14 are purified by simple crystallization and cleaved with recovery of the chirophore to provide optically pure DELTA-2-isoxazolines 15.

引用

页码：4893 / 4896

页数：4

共 11 条

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