INTERCELLULAR COMMUNICATION IN CULTURED RABBIT GASTRIC EPITHELIAL-CELLS

被引：42

作者：

UEDA, F ^{[1
]}

KYOI, T ^{[1
]}

MIMURA, K ^{[1
]}

KIMURA, K ^{[1
]}

YAMAMOTO, M ^{[1
]}

机构：

[1] HIROSHIMA UNIV,SCH MED,DEPT ANAT,HIROSHIMA 734,JAPAN

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1991年 / 57卷 / 03期

关键词：

D O I：

10.1254/jjp.57.321

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of drugs related to cyclic AMP and a tumor promoter, phorbol ester, on intercellular communications via gap junctions were investigated by the Lucifer Yellow-transfer method in cultured rabbit gastric epithelial cells. Cells were in contact with each drug for 4 hr before the microinjection of the dye into a cell. Dye transfer capacity was significantly increased by dibutyryl cyclic AMP (10(-3) M), theophylline (10(-3) M), 3-isobutyl-1-methylxanthine (10(-4) M), forskolin (10(-6) M) and irsogladine (10(-4) M); and it was inhibited by 12-O-tetradecanoyl-phorbol-13-acetate (100 ng/ml). These results suggest that the intercellular communication between cultured rabbit gastric epithelial cells is upregulated by cyclic AMP.

引用

页码：321 / 328

页数：8