ALUMINUM NEUROTOXICITY IN EXPERIMENTAL-ANIMALS

被引：39

作者：

ERASMUS, RT

SAVORY, J

WILLS, MR

HERMAN, MM

机构：

[1] UNIV VIRGINIA,HLTH SCI CTR,DEPT PATHOL,BOX 168,CHARLOTTESVILLE,VA 22908

[2] UNIV VIRGINIA,HLTH SCI CTR,DEPT INTERNAL MED,CHARLOTTESVILLE,VA 22908

[3] UNIV VIRGINIA,HLTH SCI CTR,DEPT BIOCHEM,CHARLOTTESVILLE,VA 22908

[4] NIMH,ST ELIZABETHS HOSP,CTR NEUROSCI,NEUROPATHOL SECT,WASHINGTON,DC 20032

[5] UNIV PAPUA NEW GUINEA,DEPT PATHOL,PORT MORESBY,PAPUA N GUINEA

来源：

THERAPEUTIC DRUG MONITORING | 1993年 / 15卷 / 06期

关键词：

ALUMINUM; NEUROTOXICITY; NEURODEGENERATION;

D O I：

10.1097/00007691-199312000-00024

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Neurotoxic effects of aluminum (Al) were recognized >100 years ago, but have only recently been studied in detail. By far, the most dramatic effect of Al is that of producing intraneuronal perikaryal neurofilamentous aggregates, which consist of phosphorylated neurofilaments. Several species have been used to demonstrate this effect, rabbit being most common; the effect also is seen in in vitro systems. Besides its role in producing neurofibrillary pathology, Al appears to modify the blood-brain barrier and exert cholinergic and noradrenergic effects. Possible mechanisms of Al neurotoxicity could be related to cell damage via free radical production, impairment of glucose metabolism, and effects on signal transduction.

引用

页码：588 / 592

页数：5

共 41 条

[11] FERRITIN - ISOLATION OF ALUMINUM FERRITIN COMPLEX FROM BRAIN [J].