CLASTOGENICITY TO THE MOUSE BONE-MARROW OF THE MOUSE GERM-CELL GENOTOXIN STREPTOZOTOCIN

被引：13

作者：

LIEGIBEL, U

TINWELL, H

CALLANDER, RD

SCHMEZER, P

ASHBY, J

机构：

[1] ICI PLC, CENT TOXICOL LAB, ALDERLEY PK, MACCLESFIELD SK10 4TJ, CHESHIRE, ENGLAND

[2] GERMAN CANC RES CTR, INST TOXICOL & CHEMOTHERAPY, W-6900 HEIDELBERG 1, GERMANY

来源：

MUTAGENESIS | 1992年 / 7卷 / 06期

关键词：

D O I：

10.1093/mutage/7.6.471

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The methylating agent streptozotocin is active in the mouse bone marrow micronucleus assay following a single intraperitoneal injection of 150 - 180 mg/kg. This correlates with its previously reported toxicity to mouse germ cells when administered by the same route of exposure. The potent mutagenicity of streptozotocin to strain G46 of Salmonella typhimurium is compared with its much weaker activity in strain TA1535. The genotoxicity of streptozotocin in vivo is reviewed.

引用

页码：471 / 474

页数：4

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