CONTRACEPTIVE EFFICACY OF CARICA-PAPAYA SEED EXTRACT IN MALE-MICE (MUS MUSCULUS)

被引:23
作者
CHINOY, NJ [1 ]
DSOUZA, JM [1 ]
PADMAN, P [1 ]
机构
[1] GUJARAT UNIV,SCH SCI,COSIST,ZOOL PROGRAMME,AHMEDABAD 380009,GUJARAT,INDIA
关键词
CARICA PAPAYA; ANTIFERTILITY; RODENTS; SPERM MOTILITY; CAUDA EPIDIDYMIS;
D O I
10.1002/ptr.2650090108
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The effects of an aqueous extract of Carica papaya seeds (20 mg/kg body weight/animal/day orally and 5 mg/kg body weight/animal/day i.m. for 60 days) were investigated for contraceptive efficacy and other related side effects in mate albino mice, Mus musculus, The data revealed that the extract might be causing an androgen deprived effect to target organs resulting in alterations in the internal milieu of the cauda epididymis especially. The treatment did not, however, affect the testicular sperm count suggesting that it acted at the post-testicular level which lead to a reduction of cauda epididymal sperm motility and thus the treatment brought about a significant reduction in fertility rate, The induced effects were transient and reversible upon withdrawal of the treatment, elucidating that functional sterility could be induced by the aqueous papaya seed extract in rodents.
引用
收藏
页码:30 / 36
页数:7
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