INTRALESIONAL ADMINISTRATION OF I-131-LABELED MONOCLONAL-ANTIBODIES IN THE TREATMENT OF MALIGNANT GLIOMAS

被引：15

作者：

ARISTA, A

STURIALE, C

RIVA, P

TISON, V

FRATTARELLI, M

MOSCATELLI, G

FRANCESCHI, G

SPINELLI, A

机构：

[1] OSPED GEN PROVINCIALE M BUFALINI,DEPT NUCL MED,I-47023 CESENA,ITALY

[2] OSPED GEN PROVINCIALE M BUFALINI,IST ONCOL ROMAGNOLO,I-47023 CESENA,ITALY

[3] OSPED GEN PROVINCIALE M BUFALINI,PATHOL SERV,I-47023 CESENA,ITALY

来源：

ACTA NEUROCHIRURGICA | 1995年 / 135卷 / 3-4期

关键词：

MALIGNANT GLIOMA; MONOCLONAL ANTIBODIES; RADIOIMMUNOTHERAPY; TENASCIN;

D O I：

10.1007/BF02187762

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors report their preliminary experience with the use of radiolabelled monoclonal antibodies (MAb) as an adjuvant treatment for 33 malignant gliomas. MAbs employed in this study are raised against Tenascin (TN) which is an antigen of the extracellular matrix of the tumour. It has also been found in neoplastic cells but never in normal brain tissue. This therapy is aimed to give a local high dose radiation (boost) while sparing healthy brain structures. This treatment has always been well tolerated and no adverse reactions at the level of CNS or major extraneural organs has been observed. Significant improvement of median survival has been obtained but this result should be cautiously evaluate since the study is non-randomized. Comparison with other current adjuvant technique is briefly discussed.

引用

页码：159 / 162

页数：4

共 13 条

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