ON THE FUNCTION OF THE NADP-DEPENDENT ISOCITRATE DEHYDROGENASE ISOENZYMES IN LIVING ORGANISMS

被引：86

作者：

GALVEZ, S

GADAL, P

机构：

[1] Institut de Biotechnologie des Plantes, Université de Paris-Sud., F-91405 Orsay Cédex

来源：

PLANT SCIENCE | 1995年 / 105卷 / 01期

关键词：

ISOCITRATE DEHYDROGENASE; PHYSIOLOGICAL ROLE; ISOENZYME;

D O I：

10.1016/0168-9452(94)04041-E

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

NADP-dependent isocitrate dehydrogenase (ICDH) catalyses the oxidative decarboxylation of isocitrate to yield 2-oxoglutarate. Even if an ICDH activity is widely present in living organisms, the physiological role of this protein remains completely unknown. The situation is further complicated by the presence, in eukaryotic cells, of several ICDH isoenzymes located in different subcellular compartments, as well as by their unstability. In an attempt to advance the understanding on the function(s) of these isoenzymes in plants, we have decided to compare the properties and the physiological roles of the ICDH from other organisms with the higher plant ICDH isoenzymes. In this review, we make the point on the current knowledge of the physiological role of the E. coli, yeast and mammalian enzymes. The convenience of utilizing these data to study the physiological roles of the plant ICDHs is discussed.

引用

页码：1 / 14

页数：14

共 84 条

[81] Yamazaki, Tolbert, Enzymatic characterization of leaf peroxisomes, J. Biol. Chem., 245, pp. 5137-5144, (1970)
[82] Attucci, Contribution à l'étude du metabolism energétique et carboné dans des mitochondries de semences de tournesol en germination, Thèse de doctorat, (1991)
[83] Sorrosh, Dixon, Molecular characterization and expression of an isocitrate dehydrogenase from alfalfa (Medicago sativa L), Plant Molecular Biology, 20, pp. 801-807, (1992)
[84] Udvardi, -McDermott, Kahn, Isolation and characterization of a cDNA encoding NADP-specific isocitrate dehydrogenase from soybean (Glycine max), Plant Mol. Biol., 21, pp. 739-752, (1993)

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