SYNTHESIS OF SIALIC-ACID THROUGH ALDOL CONDENSATION OF GLUCOSE WITH OXALACETIC ACID

被引：13

作者：

YAMAMOTO, T ^{[1
]}

TESHIMA, T ^{[1
]}

INAMI, K ^{[1
]}

SHIBA, T ^{[1
]}

机构：

[1] PROT RES FDN,4-1-2 INA,OSAKA 562,JAPAN

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 03期

关键词：

SIALIC ACID; N-ACETYLNEURAMINIC ACID; ALDOL CONDENSATION; GLUCOSE; PHENYLCARBAMOYL PROTECTION;

D O I：

10.1016/S0040-4039(00)74122-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Acetylneuraminic acid (sialic acid) 1 was synthesized through relatively short steps from D-glucose via a key intermediate 1,5-lactone derivative obtained from the pyranose isomer of the aldol condensation products of D-glucose with oxalacetic acid.

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页码：325 / 328

页数：4

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