OVARIAN CONTROL OF FOLLICLE DEVELOPMENT

A variety of ovarian autocrine and paracrine factors may modulate folliculogenesis and steroid production. The developmental program that leads to the production of a dominant follicle involves a precise quantitative and temporal pattern of expression of a large number of genes. Follicle-stimulating hormone plays an essential role in this process, and no other ligand by itself can serve in this regulatory capacity. it is clear that a variety of growth factors can modulate follicle-stimulating hormone action by autocrine and paracrine mechanisms. Advances in the understanding of the role of growth factors, particularly the family of insulin-like growth factor-related proteins, in regulating follicle-stimulating hormone action are discussed. It is likely that complex interactions exist between follicle-stimulating hormone and the growth factors. Significantly, growth factor regulation by pituitary gonadotropins is probably a central feature of their expression. With increased understanding of the ovarian control of follicle development, it is hoped that newer and more effective regimens for synchronous follicular and oocyte maturation can be realized.