MICE DEFICIENT IN IL-1-BETA-CONVERTING ENZYME ARE DEFECTIVE IN PRODUCTION OF MATURE IL-1-BETA AND RESISTANT TO ENDOTOXIC-SHOCK

被引：1293

作者：

LI, P

ALLEN, H

BANERJEE, S

FRANKLIN, S

HERZOG, L

JOHNSTON, C

MCDOWELL, J

PASKIND, M

RODMAN, L

SALFELD, J

TOWNE, E

TRACEY, D

WARDWELL, S

WEI, FY

WONG, W

KAMEN, R

SESHADRI, T

机构：

[1] BASF Bioresearch Corporation, Worcester, MA 01605-4314

来源：

CELL | 1995年 / 80卷 / 03期

关键词：

D O I：

10.1016/0092-8674(95)90490-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

IL-1 beta-converting enzyme (ICE) cleaves pro-IL-1 beta to generate mature IL-1 beta. ICE is homologous to other proteins that have been implicated in apoptosis, including CED-3 and Nedd-2/Ich-1. We generated ICE-deficient mice and observed that they are overtly normal but have a major defect in the production of mature IL-1 beta after stimulation with lipopolysaccharide. IL-1 alpha production is also impaired. ICE-deficient mice are resistant to endotoxic shock. Thymocytes and macrophages from the ICE-deficient animals undergo apoptosis normally. ICE therefore plays a dominant role in the generation of mature IL-1 beta, a previously unsuspected role in production of IL-1 alpha, but has no autonomous function in apoptosis.

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收藏

页码：401 / 411

页数：11

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