MOLECULAR-BASIS OF HUMAN HYPERTENSION - ROLE OF ANGIOTENSINOGEN

被引：1606

作者：

JEUNEMAITRE, X

SOUBRIER, F

KOTELEVTSEV, YV

LIFTON, RP

WILLIAMS, CS

CHARRU, A

HUNT, SC

HOPKINS, PN

WILLIAMS, RR

LALOUEL, JM

CORVOL, P

机构：

[1] UNIV UTAH, HLTH SCI CTR, ECCLES INST HUMAN GENET, DEPT HUMAN GENET, SALT LAKE CITY, UT 84112 USA

[2] COLL FRANCE, INSERM U36, F-75005 PARIS, FRANCE

[3] BRIGHAM & WOMENS HOSP, DIV ENDOCRINE HYPERTENS, BOSTON, MA 02115 USA

[4] HARVARD UNIV, SCH MED, BOSTON, MA 02115 USA

[5] UNIV UTAH, HLTH SCI CTR, CARDIOVASC GENET RES CLIN, SALT LAKE CITY, UT 84112 USA

来源：

CELL | 1992年 / 71卷 / 01期

关键词：

D O I：

10.1016/0092-8674(92)90275-H

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Essential hypertension is a common human disease believed to result from the interplay of multiple genetic and environmental determinants. In genetic studies of two large panels of hypertensive sibships from widely separated geographical areas, we obtained evidence of genetic linkage between the angiotensinogen gene (AGT) and hypertension, demonstrated association of AGT molecular variants with the disease, and found significant differences in plasma concentrations of angiotensinogen among hypertensive subjects with different AGT genotypes. The corroboration and replication afforded by these results support the interpretation that molecular variants of AGT constitute inherited predispositions to essential hypertension in humans.

引用

页码：169 / 180

页数：12

共 58 条

[21] DIRECT DETECTION AND AUTOMATED SEQUENCING OF INDIVIDUAL ALLELES AFTER ELECTROPHORETIC STRAND SEPARATION - IDENTIFICATION OF A COMMON NONSENSE MUTATION IN EXON-9 OF THE HUMAN LIPOPROTEIN-LIPASE GENE [J].